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for the 40th Annual School of Pharmacy Alumni Awards and Reunion Banquet to be held on Saturday, April 10, 2010 at the Lewis B. Rome Commons Ballroom,  UConn Storrs Campus.  Recognition of Reunion Classes 1950-1960-1970-1980-1985-1990.  All alumni are invited to attend. Watch for your invitation in the mail in February!!

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Purchase an ad to honor your student in the School of Pharmacy yearbook, The Capsule.

Annual Report

The School of Pharmacy Annual Report for the 2008-2009 is now available online.

Anderson A

 

anderson-amy.jpg

 

  

Amy Anderson
Ph.D.
Associate Professor of Medicinal Chemistry

University of Connecticut
School of Pharmacy
69 North Eagleville Road, Unit 3092
Storrs, Connecticut 06269-3092

Phone: (860) 486-6145
Fax: (860) 486-6857
E-Mail:amy.anderson@uconn.edu
Lab/Research Website

Educational Background

◊

B.S. Massachusetts Institute of Technology, Life Sciences
   
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Ph.D. Harvard University, Biophysics
   
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Postdoctoral Training: University of California, San Francisco, Biophysics and Biochemistry

Research Interests
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Structure-based drug design, using X-ray crystallography and molecular modeling, to discover small molecule inhibitors for protein targets of infectious diseases.
   
Selected Publications 

 ◊ Beierlein, J., Deshmukh, L., Frey, K., Vinogradova, O. and Anderson, A. (2009) “The Solution Structure of Bacillus anthracis Dihydrofolate Reductase Yields Insight into the Analysis of Structure-Activity Relationships for Novel Inhibitors” Biochemistry 48: 4100-4108.
   
 ◊ Frey, K., Liu, J., Lombardo, M., Bolstad, D., Wright, D. and Anderson, A. (2009) “Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternative Conformation of NADPH that may be Linked to Trimethoprim Resistance” J. Mol. Biol. 387: 1298-1308.
   
 ◊ Chen, C-Y., Georgiev, I., Anderson, A. and Donald, B. (2009) “Computational Structure-Based Redesign of Enzyme Activity” Proc. Natl. Acad. Sci. 106: 3764-3769.
   
 ◊  Sundstrom, T., Anderson, A. and Wright, D. (2009) “Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity” Org. Biomol. Chem. 7: 840-850.
   
 ◊  Liu, J., Bolstad, D., Smith, A., Priestley, N., Wright, D. and Anderson, A. (2009) “Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors” Chem. Biol. Drug Des. 73:62-74.
   
 ◊  Liu, J., Bolstad, D., Bolstad, E., Wright, D. and Anderson, A. (2009) “Towards New Antifolates Targeting Eukaryotic Opportunistic Infections” Euk. Cell, 8: 483-486.
   
 ◊ Bolstad, E. and Anderson, A. (2009) “In pursuit of virtual lead optimization: Pruning ensembles of receptor structures for increased efficiency and accuracy during docking” Proteins, 75: 62-74. 
   
 ◊ Blauvelt, M., Khalili, M., Jang, W., Paulsen, J., Anderson, A., Wilson, S. B. and Howell, A. (2008) “α-S-GalCer: Synthesis and Evaluation for iNKT Cell Stimulation” Bioorg. Med. Chem. Lett.,18: 6374-6376.
   
 ◊ Beierlein, J., Frey, K., Bolstad, D., Pelphrey, P., Joska, T., Smith, A., Priestley, N.,  Wright, D. and Anderson, A. (2008) “Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase” J. Med. Chem., 51: 7532-7540.
   
 ◊ Bolstad, D., Bolstad, E., Frey, K., Wright, D. and Anderson, A. (2008) “A structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from Cryptosporidium” J. Med. Chem., 51:6839-6852.
   
 ◊ Liu, J., Bolstad, D., Smith, A., Priestley, N., Wright, D. and Anderson, A. (2008) “Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase” Chem. Biol. 15: 990-996.