Photo of Kyle Hadden

M. Kyle Hadden

  • Email
  • Phone
    • (860) 486-8446
  • Fax
    • (860) 486-6857
  • Office
    • School of Pharmacy
      Room 628
  • Mail
    • University of Connecticut
      Dept. of Pharmaceutical Sciences
      69 North Eagleville Road
      Storrs, CT 06269-3092

Associate Professor of Medicinal Chemistry

Hadden Lab Website ยป

Educational Background

  • B.S. Wofford College, Chemistry
  • Ph.D. Medical University of South Carolina, Medicinal Chemistry
  • Postdoctoral Training: University of Kansas, Medicinal Chemistry

Research Interests

  • Organic synthesis of small molecule hedgehog pathway modulators
  • Evaluation of compounds in cell-based assays for treatment of cancer and neurodegenerative disorders
  • High-throughput screening

Selected Publications

  • Hadden, M.K. (2014) Hedgehog pathway agonism: Therapeutic applications and small molecule development, ChemMedChem 9, 27-37.
  • DeBerardinis, A.M., Banerjee, U., Hadden, M.K. (2013) Identification of vitamin-D3-based hedgehog pathway inhibitors that incorporate an aromatic A-ring isostere, ACS Med. Chem. Lett. 4, 590-595.
  • DeBerardinis, A.M., Lemieux, S., Hadden, M.K. (2013) Analogues of the Inhoffen-Lythgoe diol with anti-proliferative activity, Bioorg. Med. Chem. Lett. 23, 5367-5370.
  • Sail, V., Hadden, M.K. (2013) Identification of small molecule Hes1 modulators as potential anti-cancer chemotherapeutics, Chem. Biol. & Drug Design. 81, 334-342.
  • Corman, A., DeBerardinis, A., Hadden, M.K. (2012) Structure-activity relationships for side chain oxysterol agonists of hedgehog signaling, ACS Med. Chem. Lett. 3, 828-833.
  • DeBerardinis, A., Banerjee, U., Miller, M., Lemieux, S., Hadden, M.K. (2012) Probing the structural requirements for vitamin D3 inhibition of hedgehog signaling, Bioorg. Med. Chem. Lett. 22, 4859-4863.