Photo of Michael Pikal

Michael Pikal

  • E-Mail
  • Phone
    • (860) 486-3202
  • Fax
    • (860) 486-2076
  • Office
    • School of Pharmacy
      Room 429
  • Mail
    • University of Connecticut
      Dept. of Pharmaceutical Sciences
      69 North Eagleville Road
      Storrs, CT 06269-3092

Pfizer Distinguished Endowed Chair in Pharmaceutical Technology
Professor of Pharmaceutics

Educational Background

  • B.A. St. John’s University, Minnesota, Chemistry
  • Ph.D. Iowa State University, Physical Chemistry

Research Interests

  • Lyophilization of proteins and other pharmaceuticals – process, formulation and stability
  • Solid state chemistry of proteins
  • Dynamics in the glassy state and pharmaceutical stability

Selected Publications

  • Luthra, S.A., Shalaev, E.Y., Medec, A., Hong, J., Pikal, M.J. (2012) Chemical stability of amorphous materials: Specific and general media effects in the role of water in the degradation of freeze-dried zoniporide, J. Pharm. Sci. 101(9), 3110-3123.
  • Padilla, A.M., Pikal, M.J. (2011) The study of phase separation in amorphous freeze-dried systems, part 2: Investigation of Raman mapping as a tool for studying amorphous phase separation in freeze dried protein formulations, J. Pharm. Sci.100(4), 1467-1474.
  • Patel, S.M., Pikal, M.J. (2011) Emerging Freeze-Drying Process Development and Scale-up Issues, AAPS PharmSciTech 12(1), 372-378.
  • Murdande, S.B., Pikal, M.J., Shanker, R.M., Bogner, R.H. (2010) Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis, J. Pharm. Sci. 99(3), 1254-1264.
  • Wang, B., Cicerone, M.T., Pikal, M.J. (2010) The impact of thermal treatment on the stability of freeze dried amorphous pharmaceuticals: II. Aggregation in an IgG1 Fusion Protein, J. Pharm. Sci. 99, 683-700.
  • Abdul-Fattah, A.M., Kalonia, D.S., Pikal, M.J. (2007) The challenge of drying method selection for protein pharmaceuticals: product quality implications, J. Pharm. Sci. 96(8), 1886-1916.