pharmsci_faculty - boelsterli

Urs Boelsterli

  • E-Mail
  • Phone
    • (860) 486-8087
  • Fax
    • (860) 486-5792
  • Office
    • School of Pharmacy
      Room 533
  • Mail
    • University of Connecticut
      Dept. of Pharmaceutical Sciences
      69 North Eagleville Road
      Storrs, CT 06269-3092

Boehringer Ingelheim Endowed Chair in Mechanistic Toxicology
Professor of Pharmacology &Toxicology

Educational Background

  • M.Sc. University of Zurich, Biology
  • Ph.D. University of Zurich, Biology
  • Postdoctoral Training: Institute of Toxicology, ETH, Zurich

Research Interests

  • Mechanisms of drug-induced liver injury
  • Mechanisms of drug-induced small intestinal injury
  • Mitochondria
  • Idiosyncratic drug toxicity

Selected Publications

  • Saitta, K.S., Zhang, C., Lee, K.K., Fujimoto, K., Redinbo, M.R., and Boelsterli, U.A. (2014) Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: Mode of action and pharmacokinetics, Xenobiotica 44, 28-35.
  • Lee, K.K., Fujimoto, K., Zhang, C., Schwall, C.T., Alder, N.N., Pinkert, C.A., Krueger, W., Rasmussen, T., and Boelsterli, U.A. (2013) Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes, Free Radic. Biol. Med. 65, 584-594.
  • Boelsterli, U.A., Redinbo, M.R., and Saitta, K.S. (2013) Multiple NSAID-induced hits injure the small intestine: Underlying mechanisms and novel strategies, Toxicol. Sci. 131, 654-667.
  • Boelsterli, U.A. (2013) Mechanisms underlying the hepatotoxicity of nonsteroidal anti-inflammatory drugs. In: Drug-Induced Liver Disease (Kaplowitz, N. and DeLeve, L., Eds.), Third Edition, Elsevier, San Diego, CA, pp. 343-367.
  • LoGuidice, A., Wallace, B.D., Bendel, L., Redinbo, M.R., and Boelsterli, U.A. (2012) Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice, J. Pharmacol. Exp. Ther. 341, 447-454.
  • LoGuidice, A. and Boelsterli, U.A. (2011) Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition, Hepatology 54, 969-978.