Manish Shah

  • E-Mail
  • Phone
    • (860) 486-3103
  • Fax
    • (860) 486-5792
  • Office
    • School of Pharmacy
      Room 523
  • Mail
    • University of Connecticut
      Dept. of Pharmaceutical Sciences
      69 North Eagleville Road
      Storrs, Connecticut 06269-3092

Assistant Research Professor of Pharmacology & Toxicology

Lab Website »

Educational Background

  • B.Pharm., Pharmaceutical Sciences, Karnatak University, India
  • M.Sc., Applied Biomolecular Technology, University of Nottingham, UK
  • Ph.D., Structural Biology and Drug Discovery, University of Nottingham, UK
  • Postdoctoral Training: Hauptman-Woodward Institute (University at Buffalo), and University of California, San Diego

Research Interests

  • X-ray crystallography
  • Structural biology in drug discovery and drug metabolism
  • Structure-function studies of membrane-associated proteins

Selected Publications

  • Manish B. Shah, Jingbao Liu, Lu Huo, Qinghai Zhang, M. Denise Dearing, P. Ross Wilderman, Grazyna D. Szklarz, C. David Stout, and James R. Halpert. (2016). Structure-Function Analysis of Mammalian CYP2B Enzymes using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism. Molecular Pharmacology. 89 (4): 1-11.
  • Manish B. Shah, P. Ross Wilderman, Jingbao Liu, Hyun-Hee Jang, Qinghai Zhang, C. David Stout and James R. Halpert. (2015). Structural and Biophysical Characterization of Human Cytochromes P450 2B6 and 2A6 Bound to Volatile Hydrocarbons: Analysis and Comparison. Molecular Pharmacology. 87 (4): 649-59.
  • P. Ross Wilderman, Manish B. Shah, Hyun-Hee Jang, C. David Stout, James R. Halpert. (2013). Structural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6. J Am Chem Soc. 135(28): 10433-40.
  • Manish B. Shah, P. Ross Wilderman, Jaime Pascual, Qinghai Zhang, C. David Stout, and James R. Halpert. (2012). Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed Upon Binding Multiple Amlodipine Molecules. Biochemistry. 51(37): 7225-38.
  • Manish B. Shah, Cheryl Ingram-Smith, Leroy L. Cooper, Qu Jun, Yu Meng, Kerry S. Smith, and Andrew M. Gulick. (2009). The 2.1 Å crystal structure of an Acyl-CoA synthetase from Methanosarcina Acetivorans reveals an alternate acyl-binding pocket for small-branched acyl substrates. Proteins. 77(3): 685-98.
  • Manish Shah, Geoffrey Wells, Tracey D. Bradshaw, Charles A. Laughton, Malcolm F.G. Stevens and Andrew D. Westwell. (2006). Antitubercular Properties of Substituted Hydroxycyclohexadienones. Letters in Drug Design and Discovery. 3(6): 419-423(5).