P. Ross Wilderman

  • E-Mail
  • Phone
    • (860) 486-3103
  • Fax
    • (860) 486-5792
  • Office
    • School of Pharmacy
      Room 523
  • Mail
    • University of Connecticut
      Dept. of Pharmaceutical Sciences
      69 North Eagleville Road
      Storrs, Connecticut 06269-3092

Assistant Research Professor of Pharmacology & Toxicology

Lab Website »

Educational Background

  • B.S. in Molecular Biology, University of Wyoming
  • Ph.D. in Biochemistry, Iowa State University
  • Postdoctoral Training: University of California, San Diego

Research Interests

  • Structure and function of drug metabolizing enzymes
  • Biochemical toxicology

Selected Publications

  • Wilderman, P.R., Jang, H.H., Malenke, J.R., Salib, M., Angermeier, E., Lamime, S., Dearing, M.D., Halpert, J.R. (2014) “Functional Characterization of Cytochromes P450 2B from the desert woodrat Neotoma lepida.” Toxicol Appl Pharm. 274(3): 393-401.
  • Wilderman, P.R., Shah, M.B., Jang, H.H., Stout, C.D., Halpert, J.R. (2013) “Structural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6.” J Am Chem Soc. 135(28): 10433-40.
  • Shah, M.B., Wilderman, P.R., Pascual, J., Zhang, Q., Stout, C.D., Halpert, J.R. (2012) “Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed Upon Binding Multiple Amlodipine Molecules.” Biochemistry. 51(37): 7225-38.
  • Wilderman, P.R., Gay, S.C., Jang, H.H., Zhang, Q., Stout, C.D., Halpert, J.R. (2012) “Investigation by Site-Directed Mutagenesis of the Role of Cytochrome P450 2B4 Non-Active Site Residues in Protein-Ligand Interactions Based on Crystal Structures of the Ligand-Bound Enzyme.” FEBS J. 279(9): 1607-20.
  • Wilderman, P.R., Shah, M.B., Liu, T., Li, S., Hsu, S., Roberts, A.G., Goodlett, D.R., Woods, V.L., Stout, C.D., Halpert, J.R. (2010). “Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-Ray Crystallography.” J Biol Chem. 285(49): 38602-11.