YAFI Online Programming // Disease State Management and Drug Therapy

PSA (Prostate Specific Advancements)

Understanding Supportive Care, Updated Guidelines, and Novel Medications

Educational Objectives

After participating in this activity, pharmacists will be able to:

  • DESCRIBE current diagnostic methods and classifications for prostate cancer
  • LIST new treatment options for prostate cancer and their monitoring parameters
  • RECALL supportive care interventions for patients experiencing troubling symptoms
  • APPLY the principles of motivational interviewing to patients who have prostate cancer to improve medication adherence

After participating in this activity pharmacy technicians will be able to:

  • RECALL common symptoms of prostate cancer and the typical medications used to treat them
  • IDENTIFY medications that are typically appropriate for symptom management in patients with prostate cancer
  • RECOGNIZE when to refer patients to the pharmacist for recommendations

Session Offered

Release Date: May 1, 2020

Expiration Date: May 1, 2022

Course Fee

Free

Session Codes

20YC39-KXB22-Pharmacist

20YC39-TFB39-Pharmacy Technician

Accreditation Hours

2.0 hours of CE

Abstract

Prostate cancer is the most common cancer diagnosed in men. Most men are diagnosed with localized prostate cancer. Treatment varies depending on men's risk factors for developing advanced disease. Recently the classification for localized prostate cancer has been updated to categorize patients who may benefit from additional diagnostic testing and treatment options. Surgery, radiation, and androgen deprivation therapy (i.e., hormonal therapy) are the mainstays of localized prostate cancer treatment. Those with very high risk disease now may also benefit from the addition of chemotherapy with docetaxel. Men whose cancer has progressed also have new therapeutic options. Second-generation antiandrogens including apalutamide, darolutamide, and enzalutamide can be used for non-metastatic castrate-resistant prostate cancer. In those with newly diagnosed metastatic disease, apalutamide and enzalutamide are also now options. To date, targeted therapy has not been useful in prostate cancer. However, a small number of patients may have mutations that will respond to targeted therapy. Olaparib may now be considered for a select group of patients with DNA repair gene mutations. These new treatment advancements in prostate cancer require the pharmacy team to be familiar with common side effects and methods to mitigate them. Appropriate monitoring and supportive care therapies that facilitate patient adherence and tolerance of therapy should be included as part of the continuum of care.

Accreditation Statements

The University of Connecticut School of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

Pharmacists and pharmacy technicians are eligible to participate in this application-based activity and will receive up to 0.2 CEU (2 contact hours) for completing the activity, passing the quiz with a grade of 70% or better, and completing an online evaluation. Statements of credit are available via the CPE Monitor on- line system and your participation will be recorded with CPE Monitor within 72 hours of submission

ACPE UAN:
0009-0000-20-039-H01-P
0009-0000-20-039-H01-T

Grant funding: Astellas Pharma Glob

Cost: Free

Initial Release Date: May 1, 2020
Expiration Date: May 1, 2022

To obtain CPE credit, visit the UConn Online CE Center

Use your NABP E-profile ID and the session code 20YC58-VXT84 for pharmacists or 20YC58-HBC49 for pharmacy technicians to access the online quiz and evaluation.

First- time users must pre-register in the Online CE Center. Test results will be displayed immediately and your participation will be recorded with CPE Mon- itor within 72 hours of completing the requirements.

For questions concerning the online CPE activities, email joanne.nault@uconn.edu

Faculty

Lisa M. Holle, PharmD, BCOP, FHOPA, FISOPP, Associate Clinical Professor, University of Connecticut (UConn) School of Pharmacy and UConn Health Neag Cancer Center

Faculty Disclosure

The author has no actual or potential conflicts of interest associated with this article.

Disclosure of Discussions of Off-label and Investigational Drug Use

This activity may contain discussion of off label/unapproved use of drugs. The content and views presented in this educational program are those of the faculty and do not necessarily represent those of the University of Connecticut School of Pharmacy. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Content

Introduction

Prostate cancer is the most common cancer diagnosed in men and the second leading cause of cancer-related deaths.1 It arises in the prostate gland, which is a solid, round, heart-shaped organ positioned between the bladder and urogenital diaphragm. It is comprised of secretory cells. Its main function is secreting fluid that nourishes and protects sperm. Normal growth and differentiation of the prostate gland depends on presence of androgens, specifically dihydrotestosterone.2 Both the testes and adrenal glands are major sources of circulating androgens, such as dihydrotestosterone.

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