YAFI Online Programming // Disease State Management and Drug Therapy

Sickle Cell Disease

Dispelling Myths, Making Clinical Progress

Educational Objectives

After participating in this activity, pharmacists will be able to:

  • Describe SCD’s different phenotypes and implications for therapy
  • Classify the new therapies for adult and pediatric SCD patients
  • Describe the pharmacist’s responsibilities and opportunities in management of SCD patients
  • Review investigational agents in the pipeline for SCD
  • After completing this continuing education activity, pharmacy technicians will be able to
  • Compare the cost savings of newer agents to the standard of care—hydroxyurea
  • Describe SCD’s different phenotypes and implications for therapy
  • Determine when to refer patients to the pharmacist for recommendations or referrals

Sickle Cell Disease Image

Session Offered

Release Date: April 15, 2021

Expiration Date: April 15,2024

Course Fee

Free

Session Codes

21YC13-XRT83 Pharmacists

21YC13-BXV96 Pharmacy Technician

Accreditation Hours

2.0 hours of CE

Abstract

Sickle cell disease (SCD) is an inherited genetic disorder that affects the African American community disproportionally. Research has grown SCD knowledge by leaps and bounds from Dr. James Herrick’s description of peculiar shaped red blood cells in 1910 to the innovative CRISPR-cas9 technology. With a multifaceted pathophysiology triggered by a single amino acid substitution, SCD can cause varying degrees of chronic hemolytic anemia, vasculopathy, vaso-occlusive disease, and multiple-organ damage. Ultimately, it can shorten a patient’s life span.

Patients with SCD experience considerable barriers to therapy. Three key strategies for preventing SCD complications are screening, prevention of infection or vaso-occlusive crisis (VOC), and immunizations. This activity focuses on SCD’s complications and the therapeutic agents available to treat SCD.

Accreditation Statements

The University of Connecticut School of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

Pharmacists and pharmacy technicians are eligible to participate in this application-based activity and will receive up to 0.2 CEU (2 contact hours) for completing the activity, passing the quiz with a grade of 70% or better, and completing an online evaluation. Statements of credit are available via the CPE Monitor on- line system and your participation will be recorded with CPE Monitor within 72 hours of submission

ACPE UAN:
0009-0000-21-013-H01-P
0009-0000-21-013-H01-T

Grant funding: Novartis

Cost: Free

Initial Release Date: April 15, 2021
Expiration Date: April 15, 2024

To obtain CPE credit, visit the UConn Online CE Center

Use your NABP E-profile ID and the session code 21YC13-XRT83 for pharmacists or 21YC13-BXV96 for pharmacy technicians to access the online quiz and evaluation.

First- time users must pre-register in the Online CE Center. Test results will be displayed immediately and your participation will be recorded with CPE Mon- itor within 72 hours of completing the requirements.

For questions concerning the online CPE activities, email joanne.nault@uconn.edu

Faculty

Bisni Narayanan, Pharm D, MS, Pharmacy Supervisor- Operations, Yale New Haven Health Systems, Outpatient Pharmacy Services, Hamden, CT

Faculty Disclosure

The author has no actual or potential financial conflicts of interest associated with this article.

Disclosure of Discussions of Off-label and Investigational Drug Use

This activity may contain discussion of off label/unapproved use of drugs. The content and views presented in this educational program are those of the faculty and do not necessarily represent those of the University of Connecticut School of Pharmacy. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Content

Introduction

Sickle cell disease (SCD) is an inherited, lifelong blood disorder causing severe complications involving multiple organ systems. SCD affects approximately 100,000 Americans.1 Disproportionately affecting the Black or African American community, 1 of every 365 Black or African American babies is born with SCD. About 1 in 13 Black or African American babies is born with sickle cell trait, meaning they carry the gene mutation but do not express the disease (see SIDEBAR). Physician James Herrick described SCD about 100 years ago after observing a case of severe malaise and anemia in a young dental student from Grenada.2 Linus Pauling’s discovery of the abnormal protein hemoglobin S as the cause of SCD paved the way for treating SCD as a “molecular disease.”

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