Debra Kendall

Board of Trustees

Distinguished Professor of Medicinal Chemistry

Department of Pharmaceutical Sciences


Educational Background

  • B.A. Smith College, Biochemistry
  • Ph.D. Northwestern University, Biochemistry
  • Postdoctoral Training: Rockefeller University

Research Interests

  • Biochemical and biophysical analyses of membrane-interactive proteins
  • Cannabinoid receptor activation and signal transduction
  • Allosteric modulation of GPCRs including biased signaling outcomes

Selected Publications

  • Jagla, C.A., Scott, C.E., Tang, Y., Qiao, C., Mateo-Semidey, G.E., Yudowski, G.A., Lu, D. and Kendall, D.A.  (2018) Allosteric Modulators from Pyrimidinyl Biphenylureas Activate the Cannabinoid Receptor 1 and Utilize βArrestin, Mol. Pharm., in press.
  • Ogawa, L.M., Burford, N.T., Liao, Y.-H., Scott, C.E., Hine, A.M., Dowling, C., Chin, J., Power, M., Hunnicutt Jr., E.J., Emerick, V.L., Banks, M., Zhang, L., Gerritz, S.W., Alt, A. and Kendall, D.A. (2018) Discovery of Selective Cannabinoid CB2 Receptor Agonists by High-throughput Screening, SLAS Discovery 23, 375-383.
  • Dopart, R., Lu, D., Lichtman, A.H. and Kendall, D.A. (2018) Allosteric Modulators of   Cannabinoid Receptor 1: Developing Compounds for Improved Specificity, Drug Metab. Rev. 50, 3-13.
  • C. Nogueras-Ortiz,  Roman-Vendrell, C., Mateo-Semidey, G.E., Liao, Y.-H. Kendall, D.A., and Yudowski, G.A. (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors, Mol. Biol. Cell 28, 3554-3561.
  • Khurana, L., Fu, B., Duddupudi, A., Liao, Y.-H., Immadi, S. S., Kendall, D.A. Lu, D. (2017)    Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1. J. Med. Chem. 60, 1089-1104.
  • Kendall, D.A. and Yudowski, G.A. (2017) Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease. Front. Cell. Neurosci. 10, 294.
Contact Information
Emaildebra.kendall@uconn.edu
Phone(860) 486-1891
Fax(860) 486-6857
Mailing Address69 North Eagleville Road
Unit 3092
Storrs, Connecticut 06269-3092
Office LocationSchool of Pharmacy, Room 638
CampusStorrs
Linkhttp://kendalllab.uconn.edu/