Photo of James Halpert

James Halpert

  • E-Mail
  • Phone
    • (860) 486-2128
  • Fax
    • (860) 486-1553
  • Office
    • School of Pharmacy
      Room 358
  • Mail
    • University of Connecticut
      69 North Eagleville Road, Unit 3092
      Storrs, Connecticut 06269-3092

Dean, School of Pharmacy
Professor of Pharmacology & Toxicology

Lab Website »

Educational Background

  • B.A. in Scandinavian Languages, University of California at Los Angeles
  • M.S. in Toxicology, Karolinska Institute, Stockholm, Sweden
  • Ph.D. in Biochemistry, Uppsala University, Sweden

Research Interests

  • Structure and function of cytochromes P450 of the 2B and 3A subfamilies

Selected Publications

  • Davydov, D.R., Davydova, N.Y., Sineva, E.V., Kufareva, I., and Halpert, J.R. (2013). Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone. Biochem. J. 453:219-230.
  • Wilderman, P.R., Shah, M.B., Jang, H.-H., Stout, C.D., and Halpert, J.R. (2013). Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6. J.Am. Chem. Soc. 135:10433-10440.
  • Davydov, D.R., Davydova, N.Y., Sineva, E.V., and Halpert, J.R. (2015). Interactions among cytochromes P450 in microsomal membranes: Oligomerization of cytochromes P450 3A4, 3A5 and 2E1 and its functional consequences. J. Biol. Chem. 290:3850-3864.
  • Shah, M.B., Wilderman, P.R., Liu, J., Jang, H.-H., Zhang, Q., Stout, C.D., and Halpert, J.R. (2015). Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: Analysis and comparison. Mol. Pharmacol. 87:649-659.