José Manautou

  • E-Mail
  • Phone
    • (860) 486-3852
  • Fax
    • (860) 486-5792
  • Office
    • School of Pharmacy
      Room 535
  • Mail
    • University of Connecticut
      Dept. of Pharmaceutical Sciences
      69 North Eagleville Road
      Storrs, CT 06269-3092

Professor of Pharmacology & Toxicology
Interim Head, Department of Pharmaceutical Sciences

Educational Background

  • B.S. University of Puerto Rico School of Pharmacy, Pharmacy
  • Ph.D. Purdue University School of Pharmacy, Pharmacology and Toxicology
  • Postdoctoral Training: University of Connecticut School of Pharmacy, Toxicology

Research Interests

  • Target organ toxicity, particularly for the liver
  • Hepatic detoxification and disposition mechanisms
  • Hepatotoxicants and interference affecting susceptibility to chemical injury

Selected Publications

  • Seth, R.K., Das, S., Kumar, A., Chanda, A., Kadiiska, M.B., Michelotti, G., Manautou, J.E., Diehl, A.M., Chatterjee, S. (2014) CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis, Toxicol. Appl. Pharmacol. 274(1), 42-54.
  • O’Connor, M.A., Koza-Taylor, P., Campion, S.N., Aleksunes, L.M., Gu, X., Enayetallah, A.E., Lawton, M.P., Manautou, J.E. (2014) Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection), Toxicol. Appl. Pharmacol. 274(1), 156-67.
  • Tontsa, A.T., Mkounga, P., Njayou, F.N., Manautou, J.E., Kirk, M., Hultin, P.G., Nkengfack, A.E. (2013) Rubescins A, B and C: New havanensin type limonoids from root bark of trichilia rubescens (meliaceae), Chemical and Pharmaceutical Bulletin 61(11), 1178-83.
  • Masterjohn, C., Mah, E., Park, Y., Pei, R., Lee, J., Manautou, J.E., Bruno, R.S. (2013) Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to d-lactate, Exp. Biol. Med. 238(4), 360-9.
  • Krueger, W.H., Tanasijevic, B., Barber, V., Flamier, A., Gu, X., Manautou, J.E., Rasmussen, T.P. (2013) Cholesterol-secreting and statin-responsive hepatocytes from human ES and iPS cells to model hepatic involvement in cardiovascular health, PLoS ONE 8(7), e67296.
  • Hardwick, R.N., Ferreira, D.W., More, V.R., Lake, A.D., Lu, Z., Manautou, J.E., Slitt, A.L., Cherrington, N.J. (2013) Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver diseases, Drug Metab. Disposition 41(3), 554-61.