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University of Connecticut SCHOOL OF PHARMACY

A Tradition of Excellence: Preparing Leaders in Pharmacy and the Pharmaceutical Sciences Since 1925

Faculty Publications

February 2016

Department of Pharmaceutical Sciences

Addition of Monovalent Electrolytes to Improve Storage Stability of Freeze-Dried Protein Formulations.
Goshima H, Forney-Stevens KM, Liu M, Qian KK, Tyagi M, Cicerone MT, Pikal MJ.
J Pharm Sci. 2016 Feb;105(2):530-41. doi: 10.1016/j.xphs.2015.10.004. Epub 2015 Dec 30.

Synthesis and Evaluation of Osteogenic Oxysterols as Hedgehog Pathway Activators.
Maschinot CA, Corman AR, DeBerardinis AM, Hadden MK.
ChemMedChem. 2016 Feb 25. doi: 10.1002/cmdc.201500550.

Acetaminophen; From Liver to Brain: New Insights into Drug Pharmacological Action and Toxicity.
Ghanem CI, Pérez MJ, Manautou JE, Mottino AD.
Pharmacol Res. 2016 Feb 24. pii: S1043-6618(16)00053-0. doi: 10.1016/j.phrs.2016.02.020.

Quantification of Tribocharging of Pharmaceutical Powders in V-Blenders: Experiments, Multiscale Modeling, and Simulations.
Naik S, Hancock B, Abramov Y, Yu W, Rowland M, Huang Z, Chaudhuri B.
J Pharm Sci. 2016 Feb 23. pii: S0022-3549(15)00254-3. doi: 10.1016/j.xphs.2015.12.024.

Flow Cytometry Enables Multiplexed Measurements of Genetically Encoded Intramolecular FRET Sensors Suitable for Screening.
Doucette J, Zhao Z, Geyer RJ, Barra MM, Balunas MJ, Zwei-fach A.
J Biomol Screen. 2016 Feb 23. pii: 1087057116634007.

Epigenetically Mediated Spontaneous Reduction of NFAT1 Expression Causes Imbalanced Metabolic Activities of Articular Chondrocytes in Aged Mice.
Zhang M, Lu Q, Egan B, Zhong XB, Brandt K, Wang J.
Osteoarthritis Cartilage. 2016 Feb 18. pii: S1063-4584(16)01024-4. doi: 10.1016/j.joca.2016.02.003.

Current Therapeutic Role and Medicinal Potential of Scutellaria barbata in Traditional Chinese Medicine and Western Research.
Tao G, Balunas MJ.
J Ethnopharmacol. 2016 Feb 10. pii: S0378-8741(16)30053-8. doi: 10.1016/j.jep.2016.02.012.

Enhanced hepatotoxicity by acetaminophen in vanin-1 knockout mice is associated with deficient proliferative and immune responses.
Ferreira DW, Goedken MJ, Rommelaere S, Chasson L, Galland F, Naquet P, Manautou JE.
Biochim Biophys Acta. 2016 Feb 2. pii: S0925-4439(16)30027-8. doi: 10.1016/j.bbadis.2016.02.001.

Department of Pharmacy Practice

Pharmacogenetics and oral antithrombotic drugs.
Baker WL, Johnson SG.
Curr Opin Pharmacol. 2016 Feb 12;27:38-42. doi: 10.1016/j.coph.2016.01.008. [Epub ahead of print] Review.

Geriatric pharmacy training requirements: A survey of residency programs.
Niehoff KM, Jeffery SM.
Am J Health Syst Pharm. 2016 Feb 15;73(4):229-34. doi: 10.2146/ajhp140871.

Mapping of Multiple Sclerosis Walking Scale (MSWS-12) to five-dimension EuroQol (EQ-5D) health outcomes: an independent validation in a randomized control cohort.
Sidovar MF, Limone BL, Coleman CI.
Patient Relat Outcome Meas. 2016 Feb 3;7:13-8. doi: 10.2147/PROM.S96956. eCollection 2016.

January 2016

Department of Pharmaceutical Sciences

A Biocompatible and Biodegradable Protein Hydrogel with Green and Red Auto-fluorescence: Preparation, Characteri-za-tion and In Vivo Biodegradation Tracking and Mode-ling.
Ma X, Sun X, Hargrove D, Chen J, Song D, Dong Q, Lu X, Fan TH, Fu Y, Lei Y.
Sci Rep. 2016 Jan 27;6:19370. doi: 10.1038/srep19370.

Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β-Amino Acids.
Fenner AM, Engene N, Spadafora C, Gerwick WH, Balunas MJ.
Org Lett. 2016 Jan 19. [Epub ahead of print]

Department of Pharmacy Practice

Improving COPD Care in a Medically Underserved Primary Care Clinic: A Qualitative Study of Patient Perspectives.
Glasser I, Wang F, Reardon J, Vergara CD, Salvietti R, Acevedo M, Santana B, Fortunato G.
COPD. 2016 Jan 25:1-6. [Epub ahead of print]

Motivational Interviewing to Increase Postdischarge Antibiotic Adherence in Older Adults with Pneumonia.
Eyler R, Shvets K, Blakely ML.
Consult Pharm. 2016;31(1):38-43. doi: 10.4140/TCP.n.2016.38.

December 2015

Department of Pharmaceutical Sciences

Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet.
Li J, Sapper TN, Mah E, Rudraiah S, Schill KE, Chitchumroonchokchai C, Moller MV, McDonald JD, Rohrer PR, Manautou JE, Bruno RS.
Mol Nutr Food Res. 2015 Dec 17. doi: 10.1002/mnfr.201500814. [Epub ahead of print]

Formulation design and evaluation of amorphous ABT-102 nanoparticles.
Jog R, Kumar S, Shen J, Jugade N, Tan DC, Gokhale R, Burgess DJ.
Int J Pharm. 2015 Dec 15. pii: S0378-5173(15)30433-6. doi: 10.1016/j.ijpharm.2015.12.033. [Epub ahead of print]

Hedgehog and Vitamin D Signaling Pathways in Development and Disease.
Hadden MK.
Vitam Horm. 2016;100:231-53. doi: 10.1016/bs.vh.2015.10.006. Epub 2015 Dec 17.

Department of Pharmacy Practice

Therapeutic Potential and Critical Analysis of the PCSK9 Monoclonal Antibodies Evolocumab and Alirocumab.
White CM.
Ann Pharmacother. 2015 Dec;49(12):1327-35. doi: 10.1177/1060028015608487. Epub 2015 Sep 30. Review.

A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States.
Thomas Z, Bandali F, Sankaranarayanan J, Reardon T, Olsen KM; Critical Care Pharmacotherapy Trials Network.
Crit Care Med. 2015 Dec;43(12):2527-34. doi: 10.1097/CCM.0000000000001294.

Epidemiology and Economics of Adult Patients Hospitalized with Urinary Tract Infections.
Cardwell SM, Crandon JL, Nicolau DP, McClure MH, Nailor MD.
Hosp Pract (1995). 2015 Dec 16. [Epub ahead of print]

November 2015

Department of Pharmaceutical Sciences

Redox-Sensitive Nanoparticles from Amphiphilic Cholesterol-Based Block Copolymers for Enhanced Tumor Intracellular Release of Doxorubicin.
Nguyen CT, Tran TH, Lu X, Kasi RM.
Nanomedicine: Nanotechnology, Biology, and Medicine. 2015, 11(8): 2071–2082

Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells.
Rudraiah S, Gu X, Hines RN, Manautou JE.
Toxicol In Vitro. 2015 Nov 23. pii: S0887-2333(15)30017-5. doi: 10.1016/j.tiv.2015.11.016. [Epub ahead of print]

Blue-Green Algae Inhibit the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice.
Ku CS, Kim B, Pham TX, Yang Y, Wegner CJ, Park YK, Balunas M, Lee JY.
J Med Food. 2015 Nov 13. [Epub ahead of print]

The challenge of resistance in antimicrobial drug development.
Anderson AC, Wright DL.
Future Microbiol. 2015 Nov;10:1709-10. doi: 10.2217/fmb.15.75. No abstract available.

Department of Pharmacy Practice

Making a Case for Pediatric Antimicrobial Stewardship Programs.
Magsarili HK, Girotto JE, Bennett NJ, Nicolau DP.
Pharmacotherapy. 2015 Nov;35(11):1026-36. doi: 10.1002/phar.1647. Epub 2015 Nov 2. Review.

External validation of the In-hospital Mortality for Pulmonary embolism using Claims daTa (IMPACT) multivariable prediction rule.
Kohn CG, Peacock WF, Fermann GJ, Bunz TJ, Crivera C, Schein JR, Coleman CI.
Int J Clin Pract. 2015 Nov 17. doi: 10.1111/ijcp.12748. [Epub ahead of print]

AMSSM Scientific Statement Concerning Viscosupplementation Injections for Knee Osteoarthritis: Importance for Individual Patient Outcomes.
Trojian TH, Concoff AL, Joy SM, Hatzenbuehler JR, Saulsberry WJ, Coleman CI.
Clin J Sport Med. 2015 Nov 9. [Epub ahead of print]

Ranolazine for the treatment of chronic stable angina: a cost-effectiveness analysis from the UK perspective.
Coleman CI, Freemantle N, Kohn CG.
BMJ Open. 2015 Nov 6;5(11):e008861. doi: 10.1136/bmjopen-2015-008861.

 The Role of the Clinical Pharmacist in the Care of Patients With Cardiovascular Disease.
Dunn SP, Birtcher KK, Beavers CJ, Baker WL, Brouse SD, Page RL 2nd, Bittner V, Walsh MN.
J Am Coll Cardiol. 2015 Nov 10;66(19):2129-39. doi: 10.1016/j.jacc.2015.09.025. Review.

Publication Rates for Pharmaceutical Sciences Faculty Members at Nonresearch-Intensive US Schools of Pharmacy.
Bloom TJ, Schlesselman L.
Am J Pharm Educ. 2015 Nov 25;79(9):136. doi: 10.5688/ajpe799136.

October 2015

Department of Pharmaceutical Sciences

Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.
Reeve SM, Lombardo MN, Anderson AC.
Future Microbiol. 2015 Nov;10:1727-33. doi: 10.2217/fmb.15.78. Epub 2015 Oct 30.

Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes.
Lu D, Dopart R, Kendall DA.
Cell Stress Chaperones. 2015 Oct 24. [Epub ahead of print]

Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome.
Gunewardena SS, Yoo B, Peng L, Lu H, Zhong X, Klaassen CD, Cui JY.
PLoS One. 2015 Oct 23;10(10):e0141220. doi: 10.1371/journal.pone.0141220. eCollection 2015.

Effect of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice.
Smith GJ, Cichocki JA, Doughty BJ, Manautou JE, Jordt SE, Morris JB.
Environ Health Perspect. 2015 Oct 9. [Epub ahead of print]

Liposome Formation Using a Coaxial Turbulent Jet in Co-Flow.
Costa AP, Xu X, Khan MA, Burgess DJ.
Pharm Res. 2015 Oct 1. [Epub ahead of print]

Department of Pharmacy Practice

Impact of Magnesium L-Lactate on Occurrence of Ventricular Arrhythmias in Patients with Implantable Cardioverter Defibrillators: A Randomized, Placebo-Controlled Trial.
Baker WL, Kluger J, Coleman CI, White CM.
Open Cardiovasc Med J. 2015;9:83-8.

Impact of a pharmacist-led oral chemotherapy-monitoring program in patients with metastatic castrate-resistant prostate cancer.
Patel JM, Holle LM, Clement JM, Bunz T, Niemann C, Chamberlin KW.
J Oncol Pharm Pract. 2015 Oct 22 [Epub ahead of print) DOI: 1078155215612541

September 2015

Department of Pharmaceutical Sciences

Addition of Amino Acids to Further Stabilize Lyophilized Sucrose-Based Protein Formulations: I. Screening of 15 Amino Acids in Two Model Proteins.
Forney-Stevens KM, Bogner RH, Pikal MJ.
J Pharm Sci. 2015 Sep 28. doi: 10.1002/jps.24655. [Epub ahead of print]

Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver.
Tien YC, Liu K, Pope C, Wang P, Ma X, Zhong XB.
Drug Metab Dispos. 2015 Dec;43(12):1938-45. doi: 10.1124/dmd.115.066316. Epub 2015 Sep 23.

Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery.
Woodman JL, Suh MS, Zhang J, Kondaveeti Y, Burgess DJ, White BA, Prestwich GD, Kuhn LT.
Int J Cell Biol. 2015;2015:249573. doi: 10.1155/2015/249573. Epub 2015 Sep 10.

Department of Pharmacy Practice

Association between weekend admission for atrial fibrillation or flutter and in-hospital mortality, procedure utilization, length-of-stay and treatment costs.
Weeda ER, Hodgdon N, Do T, Unachukwu K, Cui A, Lundbye JB, Coleman CI.
Int J Cardiol. 2016 Jan 1;202:427-9. doi: 10.1016/j.ijcard.2015.09.053. Epub 2015 Sep 25.

Artemether-Lumefantrine Exposure in HIV-Infected Nigerian Subjects on Nevirapine-Containing Antiretroviral Therapy.
Parikh S, Fehintola F, Huang L, Olson A, Adedeji WA, Darin KM, Morse GD, Murphy RL, Taiwo BO, Akinyinka OO, Adewole IF, Aweeka FT, Scarsi KK.
Antimicrob Agents Chemother. 2015 Dec;59(12):7852-6. doi: 10.1128/AAC.01153-15. Epub 2015 Sep 21.

Cardiac MRI-confirmed mesalamine-induced myocarditis.
Baker WL, Saulsberry WJ, Elliott K, Parker MW.
BMJ Case Rep. 2015 Sep 4;2015. pii: bcr2015210689. doi: 10.1136/bcr-2015-210689.

Medication persistence and discontinuation of rivaroxaban and dabigatran etexilate among patients with non-valvular atrial fibrillation.
Nelson WW, Song X, Thomson E, Smith DM, Coleman CI, Damaraju CV, Schein JR.
Curr Med Res Opin. 2015;31(10):1831-40. doi: 10.1185/03007995.2015.1074064. Epub 2015 Sep 4.

August 2015

Department of Pharmaceutical Sciences

Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes.
Jang HH, Liu J, Lee GY, Halpert JR, Wilderman PR.
Arch Biochem Biophys. 2015 Oct 15;584:61-9. doi: 10.1016/ Epub 2015 Aug 28.

Foreign Body Reaction to Implantable Biosensors: Effects of Tissue Trauma and Implant Size.
Wang Y, Vaddiraju S, Gu B, Papadimitrakopoulos F, Burgess DJ.
J Diabetes Sci Technol. 2015 Aug 25;9(5):966-77. doi: 10.1177/1932296815601869.

Viscosity Analysis of Dual Variable Domain Immunoglobulin Protein Solutions: Role of Size, Electroviscous Effect and Protein-Protein Interactions.
Raut AS, Kalonia DS.
Pharm Res. 2015 Aug 19. [Epub ahead of print]

Antioxidant fractions of Khaya grandifoliola C.DC. and Entada africana Guill. et Perr. induce nuclear translocation of Nrf2 in HC-04 cells.
Njayou FN, Amougou AM, Fouemene Tsayem R, Njikam Manjia J, Rudraiah S, Bradley B, Manautou JE, Fewou Moundipa P.
Cell Stress Chaperones. 2015 Nov;20(6):991-1000. doi: 10.1007/s12192-015-0628-6. Epub 2015 Aug 14.

Liquid-Liquid Phase Separation in a Dual Variable Domain Immunoglobulin Protein Solution: Effect of Formulation Factors and Protein-Protein Interactions.
Raut AS, Kalonia DS.
Mol Pharm. 2015 Sep 8;12(9):3261-71. doi: 10.1021/acs.molpharmaceut.5b00256. Epub 2015 Aug 13.

Drug Distribution in Microspheres Enhances Their Anti-Inflammatory Properties in the Gottingen Minipig.
Kastellorizios M, Tipnis N, Papadimitrakopoulos F, Burgess DJ.
Mol Pharm. 2015 Sep 8;12(9):3332-8. doi: 10.1021/acs.molpharmaceut.5b00326. Epub 2015 Aug 10.

Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta.
Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH.
J Org Chem. 2015 Aug 21;80(16):7849-55. doi: 10.1021/acs.joc.5b01264. Epub 2015 Aug 5.

Department of Pharmacy Practice

Impact of the New Delhi metallo-beta-lactamase on beta-lactam antibiotics.
Zmarlicka MT, Nailor MD, Nicolau DP.
Infect Drug Resist. 2015 Aug 24;8:297-309. doi: 10.2147/IDR.S39186. eCollection 2015. Review.

Diabetes Among Refugee Populations: What Newly Arriving Refugees Can Learn From Resettled Cambodians
Wagner JS, Berthold SM, Buckley T, Kong S, Kuoch T, Scully M
Current Diabetes Reports ISSN 1534-4827 Volume 15 Number 8 Curr Diab Rep (2015) 15:1-14

Current practices in the treatment of Alzheimer’s Disease: where is the evidence after the phase III trials?”
Ehret MJ, Chamberlin KW.
Clinical Therapeutics. 2015 Aug 1;37(8):1604-16.

July 2015

Department of Pharmaceutical Sciences

Multiple tissue response modifiers to promote angiogenesis and prevent the foreign body reaction around subcutaneous implants.
Kastellorizios M, Papadimitrakopoulos F, Burgess DJ.
J Control Release. 2015 Sep 28;214:103-11. doi: 10.1016/j.jconrel.2015.07.021. Epub 2015 Jul 26.

Redox-sensitive nanoparticles from amphiphilic cholesterol-based block copolymers for enhanced tumor intracellular release of doxorubicin.
Nguyen CT, Tran TH, Amiji M, Lu X, Kasi RM.
Nanomedicine. 2015 Nov;11(8):2071-82. doi: 10.1016/j.nano.2015.06.011. Epub 2015 Jul 11.

Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.
Keshipeddy S, Reeve SM, Anderson AC, Wright DL.
J Am Chem Soc. 2015 Jul 22;137(28):8983-90. doi: 10.1021/jacs.5b01442. Epub 2015 Jul 8.

Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac.
Scialis RJ, Csanaky IL, Goedken MJ, Manautou JE..
Drug Metab Dispos. 2015 Jul;43(7):944-50. doi: 10.1124/dmd.114.061705. Epub 2015 Apr 20.

Department of Pharmacy Practice

Comparative efficacy and safety of antidiabetic drug regimens added to stable and inadequate metformin and thiazolidinedione therapy in type 2 diabetes.
Saulsberry WJ, Coleman CI, Mearns ES, Zaccaro E, Doleh Y, Sobieraj DM.
Int J Clin Pract. 2015 Nov;69(11):1221-35. doi: 10.1111/ijcp.12698. Epub 2015 Jul 28. Review.

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