Andrew Wiemer

  • E-Mail
  • Phone
    • (860) 486-3966
  • Fax
    • (860) 486-5792
  • Office
    • School of Pharmacy
      Room 633
  • Mail
    • University of Connecticut
      Dept. of Pharmaceutical Sciences
      69 North Eagleville Road
      Storrs, CT 06269-3092

Assistant Professor of Medicinal Chemistry

Wiemer Lab Website ยป

Educational Background

  • B.S. University of Notre Dame, Biology
  • M.S. Colorado State University, Biochemistry & Molecular Biology
  • Ph.D. University of Iowa, Molecular & Cellular Biology
  • Postdoctoral Training: University of Wisconsin – Madison

Research Interests

  • Signaling mechanisms of integrin regulatory proteins
  • Design and characterization of isoprenoid biosynthesis inhibitors
  • Discovery of novel therapeutics for hematological malignancies

Selected Publications

  • Wiemer, A.J., Wernimont, S.A., Cung, T.D., Bennin, D.A., Beggs, H.E., Huttenlocher, A. (2013) The focal adhesion kinase/Pyk2 inhibitor PF-562,271 impairs primary CD4+ T cell activation, Biochem Pharmacol. 86(6), 770-81.
  • Wiemer A.J., Wernimont, S.A., Huttenlocher A. (2012) Live imaging of LFA-1 dependent T cell motility and stop signals, Methods Mol. Biol. 757, 191-204.
  • Wernimont, S.A., Wiemer, A.J., Monkley, S., Critchley, D., Ludwig, T.E., Huttenlocher, A. (2011) Contact-dependent T cell activation and T cell stopping require talin1, J. Immunol. 187(12), 6256-67.
  • Wiemer, A.J., Hegde, S., Gumperz, J., Huttenlocher, A. (2011) A live imaging cell motility screen identifies prostaglandin e2 as a T cell stop signal antagonist, J. Immunol. 187(7), 3663-70.
  • Wiemer, A.J., Hohl, R.J., Wiemer D.F. (2011) Geranylgeranyl diphosphate synthase: Emerging therapeutic target, Clin. Pharmacol. Ther. 90(6), 804-12.
  • Dudakovic, A., Wiemer, A.J., Lamb, K.M., Vonnahme, L.A., Dietz, S.A., Hohl, R.J. (2008) Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with other inhibitors of isoprenoid biosynthesis, J. Pharmacol. Exp. Ther. 324(3), 1028-36.