Recent publications

• Impact of Mixing Approach and Bubble Formation on In Situ Forming Implant Properties July 1, 2026
  CONCLUSIONS: The introduction of air bubbles through pre-injection mixing could potentially impact drug release and ISFI's performance. This study elucidates the comparison between two mixing techniques as a reference in the developmental process of future products.
  Xinhao Lin
• Colloidal Stability of Amorphous Nanoparticles in Solution: Impact of Stabilizer July 1, 2026
  CONCLUSIONS: The impact of excipients was dependent on their mechanism of action. HPMCAS was the most effective particle stabilizer among all excipients evaluated, possibly due to its ability to inhibit both Ostwald ripening and coalescence.
  Akshay Narula
• Inflammation and epidermal barrier integrity, decline, and restoration: It's time to rouse the "guardians at the gate" June 30, 2026
  Epidermal barrier (EB) function is too often reduced to the role of a passive, inanimate upper strata of dead corneocytes surrounded by extruded lipids. However, this summary fails to appreciate the lower strata keratinocytes (KCs) which serve as both sensors and effectors of immune signaling and thus contribute a dynamic, responsive nature to EB and […]
  Michael L Samulevich
• Sequence-specific targeting of VEGFA genomic DNA to inhibit tumor growth June 19, 2026
  Vascular Endothelial Growth Factor A (VEGFA) is a critical regulatory gene involved in cellular proliferation, neovascularisation, and tumorigenic progression in solid tumors. Upregulation of VEGFA transcription is initiated upon the binding of Hypoxic Inducible Factor-1 (HIF-1α and HIF-1β) heterodimer to the Hypoxic Responsive Element (HRE) on the VEGFA gene within the hypoxic tumor microenvironment. Consequently, […]
  Angana De
• NanoBRET Saturation Analysis with a Novel HaloTag Ligand Reveals Butyrophilin Heteromeric Interactions Controlling γ9δ2 T Cell Activation June 18, 2026
  Human γ9δ2 T cells detect microbial phosphoantigens (pAg) through butyrophilin (BTN) family proteins; however, how multiple BTN paralogs assemble into functional signaling complexes remains unresolved. Because γ9δ2 T cell activation requires coordinated action of several BTN members rather than a single receptor pair, defining their organization in living cells is essential. Here, we apply a […]
  Girija Pawge
• Force Distribution and Contact Mechanics in Mini-Tablet Compaction: A Discrete Element Method Study June 18, 2026
  CONCLUSIONS: The results demonstrated that macroscopic compaction behavior was governed by the organization of force networks rather than particle-scale force magnitudes alone, highlighting the critical roles of particle size, polydispersity, and confinement effects in powder compaction.
  Saeed Najafian
• Targeting Herpesvirus Recombination Proteins for Antiviral Therapy June 16, 2026
  Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) remain among the most prevalent human pathogens, imposing a substantial global health burden. Recurrent orolabial and genital lesions affect millions worldwide, reflecting lifelong infection and the limited ability of current therapies to prevent reactivation and transmission. There have been no major therapeutic advances in over 40 […]
  Dennis L Wright
• Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity June 12, 2026
  Herpes simplex virus-1 (HSV-1) UL12 gene encodes a well-conserved 5' → 3' alkaline exonuclease. UL12 collaborates with the HSV single-strand DNA binding protein ICP8 to mediate recombination-dependent replication of viral DNA and is essential for the production of DNA that can be packaged into infectious virus. The UL12 gene has orthologs in the eight other […]
  Nidhi Sharma
• Hnf1aos1 as a Metabolic Coordinator of Hepatic Lipid Homeostasis and Feedback Control May 27, 2026
  Background: Long noncoding RNAs (lncRNAs) have emerged as critical regulators of hepatic metabolism and disease progression. The hepatocyte nuclear factor 1 alpha antisense 1 (HNF1A-AS1) lncRNA modulates liver-specific transcription factors; however, its physiological role in diet-dependent lipid homeostasis remains poorly defined. Methods: In this study, we investigated the mouse ortholog, Hnf1a opposite strand 1 (Hnf1aos1), […]
  Beshoy Armanios
• The intrinsically disordered protein TNIP1 forms puncta in cells and undergoes liquid-liquid phase separation in vitro May 27, 2026
  Tumor necrosis factor α-induced protein 3 (TNFAIP3)-interacting protein 1 (TNIP1) is a ubiquitin-binding protein and central repressor of cytoplasmic inflammatory signaling. We have previously shown that TNIP1 is an intrinsically disordered protein (IDP) and that endogenous TNIP1 can be found in cytoplasmic puncta. These TNIP1 protein traits led us to hypothesize that it is capable […]
  Liam E Carman
• Residual Content Impacts Critical Quality Attributes and Performance of Risperidone Microspheres May 15, 2026
  CONCLUSIONS: These findings identify residual species as a critical material attribute of PLGA microspheres and highlight the importance of polymer purification and raw-material control to ensure consistent performance of microsphere formulations.
  Saurabh Bhorkade
• API particle size governs in situ forming implant formation, microstructure evolution and performance May 7, 2026
  In situ forming implants (ISFIs) are long-acting injectable (LAI) drug delivery systems that undergo phase inversion upon contacting an aqueous environment, resulting in the formation of a semisolid-solid implant. To date, six ISFI products are commercially available, four of which are suspension-based formulations. Despite their growing clinical use, no generic ISFI products have reached the […]
  McKenzie Roy
• Epigenetic Biomarkers for Predicting Nucleoside Analog Drug Response and Resistance in Cancer May 4, 2026
  Nucleoside analogs (NAs) play a central role in cancer therapy, either through direct cytotoxicity or epigenome reprogramming. They are clinically effective but have shortcomings in their long-term effectiveness because of variable patient responses and the emergence of resistance. There is growing evidence that DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs (ncRNAs) are key […]
  John Kaszycki
• The Complex Interplay between Botanical Supplements and the Human Gut Microbiome May 1, 2026
  Botanical supplements have been used for the prevention and treatment of human diseases since ancient times and remain important, widely consumed therapeutics. While they display promising efficacy across a broad spectrum of biological activities, poor oral bioavailability often limits their utility. Upon ingestion, these compounds may remain in the gastrointestinal tract prior to absorption, during […]
  Alana T Ponte
• Manufacturing process development strategies for high concentration biologic drug products: from downstream processing to fill-finish April 25, 2026
  There is a growing demand for high-concentration protein formulations (HCPFs), driven by certain therapeutics that require high doses and the volume limitations of subcutaneous administration. However, downstream processing and fill-finish for these HCPFs plays a critical role and remains a major limitation. It accounts for nearly 60% of the total production cost and faces significant […]
  Rama Prajapati
• Investigating the role of mimosine-induced genotoxic stress through DNA repair profiling April 24, 2026
  Small molecules that induce DNA double-strand breaks (DSBs) are of significant interest for cancer therapy due to their ability to exploit repair vulnerabilities in tumor cells. Mimosine, a non-proteinogenic amino acid derived from Leucaena species, is known to cause cell-cycle arrest and DNA strand breaks, yet its interaction with DNA repair pathways remains poorly understood. […]
  Sai Pallavi Pradeep
• Loteprednol etabonate nanostructured lipid carriers for enhanced ocular bioavailability April 5, 2026
  Loteprednol etabonate (LTP), a corticosteroid approved for management of post-operative ocular inflammation and dry eye symptoms, suffers from limited ocular bioavailability and high dosing frequency in its current marketed form, Lotemax® suspension. The current study reports the development and optimization of a novel nanostructured lipid carrier (NLC) system for LTP, designed to overcome these limitations […]
  Suraj Fanse
• The scientific legacy of Martin Karplus from the perspective of his collaborators April 3, 2026
  The work of Martin Karplus, who passed away on Dec 28, 2024, was at the forefront of computational chemistry and molecular biophysics for a period of more than sixty years. His career started with a PhD in theoretical chemistry at Caltech with Linus Pauling in 1953. After performing leading research in molecular quantum chemistry for […]
  Ioan Andricioaei
• 10th anniversary: The development, implementation, and evaluation of a novel peer-assisted learning (PAL) program April 3, 2026
  CONCLUSION: The outcomes of this report suggest that including various PAL modalities in the didactic pharmacy curriculum can increase student confidence in learning and perceived performance on assessments. The PAL program presented appears feasible, effective, and sustainable.
  Nathaniel M Rickles
• Using magnetic nanoparticles to explore symbiotic interactions April 1, 2026
  All plants and animals form symbiotic associations with microbes, yet many of the underlying mechanisms associated with these interactions remain uncharacterized. There are inherent challenges to studying the cellular and metabolic interactions between eukaryotes and their microbial symbionts, thus new methodologies that enable the discovery of symbiotic processes are continually needed. Here, we explored the […]
  Dulce G Guillen Matus