Recent publications

• Molecular glues evolve from serendipity to rational design December 4, 2025
  Molecular glues (MGs) modulate protein interactions to inhibit, activate, or degrade targets. Classical MGs like thalidomide, cyclosporin, and fusicoccin were discovered serendipitously; a key challenge is to develop rational design approaches for MGs. Recent advances in knowledge of the structure-activity relationships (SAR) of MGs have resulted in rational design of new MGs. Moreover, newer structure-based […]
  Princy Shrivastav
• Liquid crystalline structure affects drug release from Pluronic® gels December 3, 2025
  Pluronic® gels loaded with Bupivacaine salt of linolenic acid (Bup-γL) were successfully developed in the past for oral mucositis pain control. The mechanisms of drug release from such Pluronic® gels have not yet been fully understood. The objective of this study was to explore the underlying mechanisms of drug release from Pluronic® gels with or […]
  Tingting Li
• The <em>Non-Coding RNA</em> Journal Club: Highlights on Recent Papers-14 November 24, 2025
  The field of non-coding RNA research is advancing at a breathtaking pace, continually uncovering new layers of regulatory complexity and functional diversity [...].
  El Cheima Mhamedi
• Iron dextran nanoparticles interacting with micrometric crosslinked protein scaffolds: Theoretical, computational and experimental results to design formulations for iron deficiency November 24, 2025
  Iron deficiency is the primary nutritional deficiency globally and iron dextran nanoparticles (IDN) are used for supplementation. Here we have applied theoretical, computational and experimental studies to understand the behavior of IDN and its interaction with a micrometric crosslinked gelatin scaffold (MCGS) to potentially develop a drug delivery system. Modeling single IDN reveals a complex […]
  Emerson Durán
• Unlocking the alternative chloride pathway in cystic fibrosis November 16, 2025
  No abstract
  Mounika Pathuri
• γ9δ2 T cells detect mevalonate diphosphate via BTN3A3 November 14, 2025
  Butyrophilins (BTNs) act as critical sensors of phosphoantigens (pAgs), mediating the immune response to these small molecules. The natural ligands for BTN3A1 include the exogenous (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) and endogenous pAgs dimethyl allyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP), all of which can bind to BTN3A1 followed by activation of γ9δ2 T cells. BTN3A1 shares […]
  Yiming Jin
• Thermal stability and dynamics of ssDNA loaded adeno-associated viral capsids: A coarse-grained molecular dynamics simulations November 12, 2025
  The study investigated the structural breakdown as a function of temperature and potential genome release of adeno-associated virus (AAV) in an aqueous environment through coarse-grained molecular dynamics (CG-MD) simulations. The factors and mechanisms influencing capsid stability using an AAV8 capsid loaded with single-stranded DNA (ssDNA) were studied across a range of 300 K, 338 K […]
  Tibo Duran
• Mechanistic Modeling of Intramuscular Administration of a Long-acting Injectable Accounting for Tissue Response At the Depot Site October 24, 2025
  The tissue response to long-acting injectables (LAIs) suspension injection may impact the product in vivo performance. One such response is the formation of an inflammatory cell layer (ICL) resulting in an envelope around the injected particles. This study aims to use a mechanistic model to describe the clinical in vivo exposure and performance of an […]
  Daniela A Silva
• LCMS/MS-Based Mining of the Peptaibiome: A Discovery of New Peptaibols October 9, 2025
  In this study, we employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to perform chemo-profiling on four fungal species: three Trichoderma species─two strains of Trichoderma asperellum (S3-3 and S3-1) and one Trichoderma longibrachiatum (FS-46)─and one species from the Tolypocladium genus, Tolypocladium inflatum (MTCC-3538). Our analysis identified 78 peptaibols featuring α-aminoisobutyric acid (Aib). Among these, we discovered both […]
  Nisha Sharma
• The effects of low-dose ketamine and (2R,6R)-Hydroxynorketamine on affective behaviors associated with protracted oxycodone withdrawal October 4, 2025
  CONCLUSIONS: These findings demonstrate the therapeutic potential of (2R,6R)-HNK and ketamine in alleviating affective symptoms of oxycodone withdrawal.
  Michael J Lehane
• Steroid hormone regulation of immunometabolism and inflammation October 3, 2025
  The metabolism of immune cells adapts to support the energy demands for their activation, differentiation, and effector functions through a process known as metabolic reprogramming. This metabolic plasticity is influenced by both extrinsic and intrinsic factors, including steroid hormones such as glucocorticoids, androgens, progestogens, and estrogens. These critical mediators modulate immune function and inflammatory responses […]
  Ley Cody Smith
• Multi-omics analysis reveals important role for microbial-derived metabolites from <em>Botryllus schlosseri</em> in metal interactions September 15, 2025
  Marine microbial communities govern many of the biological and chemical processes in the ocean, including element cycles, ecosystem health, and disease. Marine organisms are surrounded by microbes, with complex molecular interactions occurring between bacterial symbionts, eukaryotic hosts, and their pathogens or prey. Trace metals in the ocean can be either beneficial or detrimental to marine […]
  Dulce G Guillén Matus
• Physiological Considerations and Delivery Strategies for Targeting Tumors Through Intraperitoneal Delivery August 25, 2025
  The peritoneal cavity presents both unique challenges and promising opportunities for targeted therapy in malignancies like ovarian, gastric, pancreatic, and colorectal cancers. Intraperitoneal drug delivery offers significant pharmacokinetic advantages over intravenous administration by achieving high local drug concentrations and tumor-specific delivery potential while minimizing systemic toxicity. Despite these theoretical advantages, the clinical implementation of intraperitoneal […]
  Md Jobair Hossen Jony
• Visualization of CYP3A4 expression at both mRNA and protein levels simultaneously at single cell resolution in various conditions using RNAscope combined with immunofluorescence August 24, 2025
  Precise characterization of drug-metabolizing enzyme expression, such as CYP3A4, at the single-cell resolution is essential for understanding hepatic functional heterogeneity and its impact on xenobiotic clearance. In this study, we employed RNAscope in situ hybridization combined with immunofluorescence to simultaneously visualize CYP3A4 mRNA and protein expression in individual cells under diverse experimental conditions. Using differentiated […]
  Jing Jin
• MRP4 deficiency drives lipid metabolism dysregulation and adipose tissue inflammation through cAMP-CREB-CRTC2 activation August 15, 2025
  Multidrug resistance-associated protein 4 (MRP4/ABCC4), a plasma membrane transporter, plays a critical role in the efflux of endogenous metabolites and xenobiotics. Recent studies have also implicated MRP4 in adipogenesis and fatty acid metabolism. Our previous work using MRP4 knockout (MRP4^(-/-)) mice demonstrated a strong association between MRP4 deficiency and the development of obesity and diabetes. […]
  Ankit P Laddha
• Mass transport analysis of the particle drifting effect in a biphasic diffusion apparatus August 15, 2025
  Formulations containing colloidal particles, such as micelles, nanocrystals, and amorphous drug nanoparticles, are widely used to enhance the oral absorption of poor soluble drugs. The underlying mechanism was proposed to be the particle drifting effect, where the particles effectively reduce the diffusional resistance of the aqueous boundary layer by releasing the free drug near the […]
  Saurav Adhikari
• The particle drifting effect in vivo: impact of dose and animal species August 9, 2025
  The presence of drug nanoparticles is believed to promote oral drug absorption through the particle drifting effect. These particles act as vehicles that penetrate the diffusion boundary layer adjacent to the intestinal membrane, releasing the drug near the mucosal surface, and thereby enhancing drug absorption. Despite extensive in vitro studies demonstrating the potential of this […]
  Madhu Sharma
• Novel oral LAAM immediate-release capsules for treating opioid use disorder August 4, 2025
  Levo-alpha-acetylmethadol (LAAM) has a long duration of action offering numerous behavioral and clinical advantages for treating opioid use disorders. In this study, we aim to develop a novel oral immediate-release capsule of LAAM, as an alternative to methadone, the major medication that requires daily visits. LAAM solid dispersion-coated pellets were developed with VIVAPUR® MCC Spheres […]
  Zixuan Zhen
• Intracellular fatty acid levels differentially impact target silencing by FDA-approved siRNA drugs July 29, 2025
  With seven approved and many more anticipated over the next decade, small interfering RNA (siRNA) therapeutics have emerged as an innovative class of nucleic acid-based drugs, offering potential treatments for both rare and common diseases. A substantial portion of the patient population affected by these diseases may also present with obesity and metabolic-associated fatty liver […]
  Sherouk M Tawfik
• Structure and function of reader proteins that recognize methylated RNA residues July 24, 2025
  Recent years have seen significant advances in our understanding of the importance of RNA methylation as an essential mechanism of post-transcriptional regulation of gene expression. RNA methylation is a reversible process relying on the traditional classes of epigenetic 'writer', 'eraser', and 'reader' proteins to install, remove, and recognize methylated residues. While general RNA binding proteins […]
  Ruth M Ogboye