Recent publications

• REV1 inhibition enhances trinucleotide repeat mutagenesis January 15, 2026
  Trinucleotide repeat instability has been implicated in the pathogenesis of numerous neurodegenerative disorders. While germline expansions destabilize trinucleotide repeats to cause disease anticipation, somatic cell trinucleotide repeat instability drives earlier onset of symptoms and further disease progression. However, the drivers behind these repeat length changes remain unclear. Current models suggest that DNA replication slippage events […]
  Ava Siegel
• Combining anti-gene γPNA with small molecules and RNA inhibitors: A strategy to enhance anti-tumor efficacy January 15, 2026
  Targeting genomic DNA to silence oncogenes is a promising strategy for cancer therapy. Gamma peptide nucleic acid (γPNA) targeting c-Myc genomic DNA has shown established efficacy in vitro and in multiple preclinical models. In this study, we investigated a combination treatment by integrating γPNAs with direct or indirect c-Myc inhibitors to further enhance the anti-tumor […]
  Sai Pallavi Pradeep
• Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner January 13, 2026
  The bioavailability of a drug is influenced by its physicochemical properties, dissolution rate, solubility, gastrointestinal tract permeability, and its absorption, distribution, and metabolism. Zileuton, a poorly soluble biopharmaceutical classification system class II drug prescribed for the treatment of asthma, was selected as a candidate for nanocrystal drug formulation. Our previous study demonstrated that zileuton nanocrystal […]
  Sangeeta Khare
• Cocaine-Induced Changes in the BRD4 Interactome Identifies Casein Kinase 1 Epsilon as a Therapeutic Target January 12, 2026
  Recent research has revealed that BRD4, a bromodomain and extra terminal domain (BET) epigenetic "reader" protein, plays an essential role in regulating behavioral and molecular responses to cocaine. To date, the roles of BRD4 and other BET proteins in substance use disorder (SUD) models have been mainly studied using small molecule inhibitors that block the […]
  Afshin Seyednejad
• The Selective Bromodomain and Extra-Terminal Domain (BET) Inhibitor RVX-208 Reduces Cocaine-Seeking Behaviour and Alters Proteomic Pathways in the Nucleus Accumbens January 8, 2026
  Bromodomain and extra terminal domain (BET) epigenetic 'reader' proteins are key regulators of both behavioural and molecular responses to cocaine. In substance use disorder (SUD) models, BET function has primarily been investigated using small molecule inhibitors that prevent both bromodomains of BET proteins from interacting with acetylated histones. Although these inhibitors have been shown to […]
  Tyler J Sacko
• Deciphering the Role of DNA Polymerase Eta on the Incorporation and Bypass of Inosine and Cell Cycle Arrest December 30, 2025
  Inosine is a key intermediate in many cellular pathways, and our RT-qPCR data showed that DNA polymerase eta (polη) was upregulated upon the repeated treatment of inosine and inosine monophosphate (IMP) in HCT116 cells, which suggests that polη is actively involved in the incorporation and bypass of inosine in cells. To gain novel insight into […]
  Jackson C Lin
• Lung injury, oxidative stress and impaired functioning in a model of prolonged ozone exposure in female mice are associated with macrophage proinflammatory and profibrotic activation and altered bioenergetics December 14, 2025
  Prolonged exposure to ozone causes lung injury and persistent inflammation, pathologies associated with emphysema and asthma. Herein, we characterized inflammatory cells in the lungs using a murine model of prolonged ozone exposure, with the long-term goal of assessing their role in disease pathogenesis. Mice were exposed to air or ozone (1.5 ppm, 2 h, 2x/wk, […]
  Vasanthi R Sunil
• Brush-like Polymer Surface on Silk Fibroin Films for Controlled Release of Local Anesthetics December 11, 2025
  Postsurgical pain management remains a persistent challenge for patients and healthcare providers. This work presents an implantable, degradable drug release platform based on silk biomaterials designed to be placed at a desired surgical site intraoperatively to release the local anesthetic bupivacaine in a sustained manner to prevent and treat postsurgical pain. Methacrylate monomers containing different […]
  Sanyukta A Patil
• Molecular glues evolve from serendipity to rational design December 4, 2025
  Molecular glues (MGs) modulate protein interactions to inhibit, activate, or degrade targets. Classical MGs like thalidomide, cyclosporin, and fusicoccin were discovered serendipitously; a key challenge is to develop rational design approaches for MGs. Recent advances in knowledge of the structure-activity relationships (SAR) of MGs have resulted in rational design of new MGs. Moreover, newer structure-based […]
  Princy Shrivastav
• Liquid crystalline structure affects drug release from Pluronic® gels December 3, 2025
  Pluronic® gels loaded with Bupivacaine salt of linolenic acid (Bup-γL) were successfully developed in the past for oral mucositis pain control. The mechanisms of drug release from such Pluronic® gels have not yet been fully understood. The objective of this study was to explore the underlying mechanisms of drug release from Pluronic® gels with or […]
  Tingting Li
• The <em>Non-Coding RNA</em> Journal Club: Highlights on Recent Papers-14 November 24, 2025
  The field of non-coding RNA research is advancing at a breathtaking pace, continually uncovering new layers of regulatory complexity and functional diversity [...].
  El Cheima Mhamedi
• Iron dextran nanoparticles interacting with micrometric crosslinked protein scaffolds: Theoretical, computational and experimental results to design formulations for iron deficiency November 24, 2025
  Iron deficiency is the primary nutritional deficiency globally and iron dextran nanoparticles (IDN) are used for supplementation. Here we have applied theoretical, computational and experimental studies to understand the behavior of IDN and its interaction with a micrometric crosslinked gelatin scaffold (MCGS) to potentially develop a drug delivery system. Modeling single IDN reveals a complex […]
  Emerson Durán
• Unlocking the alternative chloride pathway in cystic fibrosis November 16, 2025
  No abstract
  Mounika Pathuri
• γ9δ2 T cells detect mevalonate diphosphate via BTN3A3 November 14, 2025
  Butyrophilins (BTNs) act as critical sensors of phosphoantigens (pAgs), mediating the immune response to these small molecules. The natural ligands for BTN3A1 include the exogenous (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) and endogenous pAgs dimethyl allyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP), all of which can bind to BTN3A1 followed by activation of γ9δ2 T cells. BTN3A1 shares […]
  Yiming Jin
• Thermal stability and dynamics of ssDNA loaded adeno-associated viral capsids: A coarse-grained molecular dynamics simulations November 12, 2025
  The study investigated the structural breakdown as a function of temperature and potential genome release of adeno-associated virus (AAV) in an aqueous environment through coarse-grained molecular dynamics (CG-MD) simulations. The factors and mechanisms influencing capsid stability using an AAV8 capsid loaded with single-stranded DNA (ssDNA) were studied across a range of 300 K, 338 K […]
  Tibo Duran
• Mechanistic Modeling of Intramuscular Administration of a Long-acting Injectable Accounting for Tissue Response At the Depot Site October 24, 2025
  The tissue response to long-acting injectables (LAIs) suspension injection may impact the product in vivo performance. One such response is the formation of an inflammatory cell layer (ICL) resulting in an envelope around the injected particles. This study aims to use a mechanistic model to describe the clinical in vivo exposure and performance of an […]
  Daniela A Silva
• LCMS/MS-Based Mining of the Peptaibiome: A Discovery of New Peptaibols October 9, 2025
  In this study, we employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to perform chemo-profiling on four fungal species: three Trichoderma species─two strains of Trichoderma asperellum (S3-3 and S3-1) and one Trichoderma longibrachiatum (FS-46)─and one species from the Tolypocladium genus, Tolypocladium inflatum (MTCC-3538). Our analysis identified 78 peptaibols featuring α-aminoisobutyric acid (Aib). Among these, we discovered both […]
  Nisha Sharma
• The effects of low-dose ketamine and (2R,6R)-Hydroxynorketamine on affective behaviors associated with protracted oxycodone withdrawal October 4, 2025
  CONCLUSIONS: These findings demonstrate the therapeutic potential of (2R,6R)-HNK and ketamine in alleviating affective symptoms of oxycodone withdrawal.
  Michael J Lehane
• Steroid hormone regulation of immunometabolism and inflammation October 3, 2025
  The metabolism of immune cells adapts to support the energy demands for their activation, differentiation, and effector functions through a process known as metabolic reprogramming. This metabolic plasticity is influenced by both extrinsic and intrinsic factors, including steroid hormones such as glucocorticoids, androgens, progestogens, and estrogens. These critical mediators modulate immune function and inflammatory responses […]
  Ley Cody Smith
• Multi-omics analysis reveals important role for microbial-derived metabolites from <em>Botryllus schlosseri</em> in metal interactions September 15, 2025
  Marine microbial communities govern many of the biological and chemical processes in the ocean, including element cycles, ecosystem health, and disease. Marine organisms are surrounded by microbes, with complex molecular interactions occurring between bacterial symbionts, eukaryotic hosts, and their pathogens or prey. Trace metals in the ocean can be either beneficial or detrimental to marine […]
  Dulce G Guillén Matus