Recent publications
- Characterization of Subtype Selective Cannabinoid CB<sub>2</sub> Receptor Agonists as Potential Anti-Inflammatory Agents April 30, 2021Activation of the CB(2) receptor has been shown to have anti-inflammatory and antinociceptive effects without causing psychoactive effects. Previously, we reported that the compound ethyl 2(2-(N-(2,3-dimethylphenyl) phenylsulfonamido)acetamido)benzoate (ABK5) is a CB(2) subtype selective agonist with anti-inflammatory and antinociceptive effects. In the present study, we tested four ABK5 derivatives, ABK5-1, ABK5-2, ABK5-5, and ABK5-6, to analyze […]Yaliang Tang
- Applications of Nanoparticle-Antibody Conjugates in Immunoassays and Tumor Imaging March 15, 2021Modern diagnostic technologies rely on both in vitro and in vivo modalities to provide a complete understanding of the clinical state of a patient. Nanoparticle-antibody conjugates have emerged as promising systems to confer increased sensitivity and accuracy for in vitro diagnostics (e.g., immunoassays). Meanwhile, in vivo applications have benefited from the targeting ability of nanoparticle-antibody […]Xinhao Lin
- Anti-inflammatory and antinociceptive effects of the selective cannabinoid CB<sub>2</sub> receptor agonist ABK5 March 13, 2021Cannabinoid receptors are a potential target for anti-inflammatory and pain therapeutics. There are two subtypes, CB(1) and CB(2), and Δ⁹-tetrahydrocannabinol activates both of them, providing an analgesic effect but also psychoactive side effects. The psychoactive side effects are considered to be caused by activation of CB(1), but not CB(2). ABK5 is a CB(2) subtype selective […]Yaliang Tang
- LC-MS/MS method for simultaneous quantification of dexamethasone and tobramycin in rabbit ocular biofluids March 13, 2021The complexity of Tobradex® ointment formulation (dexamethasone 0.1 wt% and tobramycin 0.3 wt%) and the high cost of pharmacokinetic (PK) studies in human aqueous humor may prevent generic drug companies from moving forward with a Tobradex®-equivalent product development. The in vitro drug release test would be an alternative approach for differentiating the generic formulations containing […]Tuo Meng
- Impact of Formulation Parameters on In Vitro Release from Long-Acting Injectable Suspensions March 12, 2021The development of long-acting injectable (LAI) suspension products has increased in recent years. A better understanding of the relationship between the physicochemical properties of these products and their in vitro as well as in vivo performance is expected to further facilitate their development and regulatory review. Using Depo-SubQ Provera 104® as the reference listed drug […]Quanying Bao
- The Long Noncoding RNA Hepatocyte Nuclear Factor 4<em>α</em> Antisense RNA 1 Negatively Regulates Cytochrome P450 Enzymes in Huh7 Cells via Histone Modifications March 6, 2021The maintenance of homeostasis of cytochromes P450 enzymes (P450s) under both physiologic and xenobiotic exposure conditions is ensured by the action of positive and negative regulators. In the current study, the hepatocyte nuclear factor 4α (HNF4A) antisense RNA 1 (HNF4A-AS1), an antisense long noncoding RNA of HNF4A, was found to be a negative regulator of […]Pei Wang
- Influence of PLGA molecular weight distribution on leuprolide release from microspheres March 6, 2021Poly (lactide-co-glycolide) (PLGA) is a biodegradable copolymer used in many long-acting drug products. The objective of the present study was to investigate the influence of polymer molecular weight distribution differences of PLGA on the in vitro release profile of leuprolide acetate microspheres. Eight microsphere formulations were prepared using the same manufacturing process but with different […]Masanori Ochi
- Stabilization and X-ray Attenuation of PEGylated Cholesterol/Polycaprolactone-Based Perfluorooctyl Bromide Nanocapsules for CT Imaging March 5, 2021Contrast-enhanced X-ray computed tomography plays an important role in cancer imaging and disease progression monitoring. Imaging using radiopaque nanoparticle platforms can provide insights on the likelihood of nanoparticle accumulation and can enable image-guided therapies. Perfluorooctyl bromide (PFOB)-loaded nanocapsules designed for this purpose were stabilized using an in-house synthesized PEGylated polycaprolactone-based copolymer (PEG-b-PCL(Ch)) and compared with […]André O'Reilly Beringhs
- Thromboembolism, bleeding and vascular death in nonvalvular atrial fibrillation patients with type 2 diabetes receiving rivaroxaban or warfarin February 27, 2021CONCLUSIONS: In nonvalvular atrial fibrillation patients with type 2 diabetes, rivaroxaban was associated with an ~ 10% relative reduction in vascular mortality and fewer bleeding-related hospitalizations versus warfarin.Craig I Coleman
- Medulloblastoma drugs in development: Current leads, trials and drawbacks February 26, 2021Medulloblastoma (MB) is the most common malignant brain tumor in children. Current treatment for MB includes surgical resection, radiotherapy and chemotherapy. Despite significant progress in its management, a portion of children relapse and tumor recurrence carries a poor prognosis. Based on their molecular and clinical characteristics, MB patients are clinically classified into four groups: Wnt, […]Jiachen Wen
- Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor February 22, 2021The glioma-associated family of transcription factors (GLI) have emerged as a promising therapeutic target for a variety of human cancers. In particular, GLI1 plays a central role as a transcriptional regulator for multiple oncogenic signaling pathways, including the hedgehog (Hh) signaling pathway. We undertook a computational screening approach to identify small molecules that directly bind […]Radha Charan Dash
- Correction to: Evaluation of Predictors of Protein Relative Stability Obtained by \Solid-State Hydrogen/Deuterium Exchange Monitored by FTIR February 17, 2021No abstractRui Fang
- Impact of powder-binder interactions on 3D printability of pharmaceutical tablets using drop test methodology February 15, 2021In this study, a pre-screening test has been developed for the binder-jet 3D printing process (BJ3DP) which has been validated using statistical analysis. The pre-screening test or drop test has been adapted from the wet granulation field and modified later on to be used for tablet manufacturing in BJ3DP. Initially, a total of eight powders […]Koyel Sen
- The growth of siRNA-based therapeutics: Updated clinical studies January 29, 2021More than two decades after the natural gene-silencing mechanism of RNA interference was elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the pharmaceutical market. With three agents already approved and many others in advanced stages of the drug development pipeline, siRNA drugs are on their way to becoming a standard modality of pharmacotherapy. […]M May Zhang
- Discrete Element Modeling (DEM) based investigation of tribocharging in the pharmaceutical powders during hopper discharge January 28, 2021Triboelectric charging is defined as the phenomenon of charge transfer between two different material surfaces when they are brought into contact and separated. The focus of this research is the development of a Discrete Element Method (DEM) based simulation model to predict tribocharging during hopper discharge. Due to decreased particle-wall interactions and reduced particle wall […]Raj Mukherjee