Recent publications
- Antifungal therapy patterns, healthcare utilization, costs, and mortality in central nervous system and non-central nervous system disseminated coccidioidomycosis across the continuum-of-care February 8, 2025CONCLUSIONS: Most patients with either CNS or non-CNS disseminated coccidioidomycosis received an azole first-line and demonstrated azole-cycling over subsequent lines. Polyenes were used in the latter lines. Patients utilized substantial healthcare resources and accrued appreciable costs, both prior to and after diagnosis.Fariba Donovan
- The Impact of Ketamine-Based Versus Non-Ketamine-Based ECT Anesthesia Regimens on the Severity of Patients' Depression and Occurrence of Adverse Events: A Systematic Review with Meta-Analysis February 6, 2025CONCLUSION: Ketamine is a promising anesthesia adjunct to ECT that may enhance antidepressant effects in exchange for more adverse events.Dakota J Sicignano
- Interrupted versus uninterrupted anticoagulation for cardiac rhythm management device insertion January 28, 2025BACKGROUND: Guideline-recommended strategies to interrupt chronic anticoagulation with warfarin or direct oral anticoagulants (DOAC) during the perioperative period of cardiac implantable electronic device (CIED) surgery differ worldwide. There is uncertainty concerning the benefits and harms of interrupted and uninterrupted anticoagulation in patients undergoing CIED surgery.Brett Chen
- Suggested Dosing of Select Beta-lactam Agents for the Treatment of Antimicrobial-Resistant Gram-Negative Infections in Children January 23, 2025The Infectious Diseases Society of America (IDSA) publishes annual guidance on the treatment of antimicrobial-resistant (AMR) gram-negative infections. Within the AMR guidance, suggested dosages of antibiotics for adults infected with AMR pathogens are provided. This document serves as a companion document to the IDSA guidance to assist pediatric specialists with dosing β-lactam agents for the […]Christine R Lockowitz
- Association Between the Need to Change Initial Antifungal Therapy and Treatment Costs in Patients With Invasive Aspergillosis January 20, 2025CONCLUSIONS: Changing antifungals was associated with longer hospital stays and costs and higher all-cause costs over 12-months.Barbara D Alexander
- Prognostic Value of Frailty in Patients With Takotsubo Cardiomyopathy January 16, 2025CONCLUSIONS: Our results suggest that frailty is useful as a prognostic factor for in-hospital events in patients with TCM.Carlos Diaz-Arocutipa
- Diagnostic models to differentiate Takotsubo syndrome from acute coronary syndrome: A systematic review and meta-analysis January 14, 2025CONCLUSION: Our review identified multiple diagnostic models to diagnose Takotsubo syndrome. Although most models showed acceptable-to-good discriminative performance, calibration measures were almost unreported and the risk of bias was a concern in most studies.Carlos Diaz-Arocutipa
- Effect of Mediterranean Diets on Cardiovascular Risk Factors and Disease in Overweight and Obese Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials January 9, 2025We systematically evaluated effects of Mediterranean diets (MED) on cardiovascular (CV) disease and risk factors in overweight or obese adults. Five engines and two registries were searched until October 2023 for randomized controlled trials (RCTs) evaluating any type of MED compared to other diets or advice in adults. Outcomes of interest were clinical outcomes and […]Adrian V Hernandez
- Assessing the Alignment Between Pharmacists' Reported Tasks and Employer-Advertised Skills January 1, 2025CONCLUSION: The fact that prescription review remains the top task from O*NET over the past 10 years and the top advertised skill in Lightcast is patient care underscores the contemporary misalignment and highlights a potential discrepancy in the emphasis of pharmacy education.Amy L Ives
- Examining the Alignment of Pharmacists' Daily Tasks, Employer-advertised Skills, and the Entrustable Professional Activities January 1, 2025CONCLUSION: Prescription processing, legal compliance, and operational pharmacy management are the most essential daily functions of today's pharmacists, contrasting with the person-centered nature of the EPAs. Amid the curricular evolution that has occurred to meet the future vision of pharmacy practice, programs must, nonetheless, continue to teach the skills required for the existing marketplace to […]Diana M Sobieraj
- Real-World Antifungal Therapy Patterns Across the Continuum of Care in United States Adults with Invasive Aspergillosis December 27, 2024Changes to antifungal therapy (AFT) in invasive aspergillosis (IA) may occur due to intolerance, side effects, drug interactions, or lack of response. We describe AFT change patterns in IA patients. This was a US claims data study. IA patients were identified during the index hospitalization from October 2015 to November 2022. Patients were stratified by […]Barbara D Alexander
- Clinical Profile and Treatment Adherence in Patients with Type 2 Diabetes and Chronic Kidney Disease Who Initiate an SGLT2 Inhibitor: A Multi-cohort Study December 17, 2024CONCLUSIONS: At a 1-year follow-up, at least half of the patients with CKD and T2D were receiving SGLT2i treatment across the data sources. In patients initiating SGLT2i, treatment options for T2D and CKD were heterogeneous and dynamic within and among data sources.Catherine B Johannes
- COEPA ready: Innovative pedagogy for integrating social determinants of health in PharmD curricula December 15, 2024CONCLUSION: These exemplars provide faculty with varied models for implementing SDH-related teaching opportunities within their institutions.Jennifer Bhuiyan
- Clinical outcomes of a twice-daily metronidazole dosing strategy for Bacteroides spp. bloodstream infections December 12, 2024CONCLUSIONS: In the largest study to date of patients with Bacteroides spp. bacteraemia treated with metronidazole, twice-daily dosing strategies were not associated with worse outcomes compared with thrice-daily dosing strategies.Sunish Shah
- Pharmacists as Partners in Pediatric Immunizations: A White Paper From the Pediatric Pharmacy Association December 11, 2024No abstractJennifer E Girotto
- Burden of Hospitalization for Coccidioidal Meningitis: An Analysis of the National Inpatient Sample, 2019-2021 December 11, 2024Coccidioidal meningitis (CM) requires lifelong aggressive management, often necessitating hospitalization. In the National Inpatient Sample (2019-2021), CM hospitalizations (N = 2305) were associated with frequent CM-related procedures (63.6% [95% confidence interval {CI}, 59.3%-67.6%]), long stays (mean, 13.0 days [95% CI, 11.3-14.6 days]), substantial costs per stay (mean, $48 155 [95% CI, $42 382-$53 929]), and […]Craig I Coleman
- Prescription for Curricular Revision: Application of Design Thinking Principles November 25, 2024Continuous quality improvement of the professional curriculum can present as a series of complex problems to solve. Schools and colleges of pharmacy would benefit from a structured framework to approach complex problem-solving while engaging faculty and students throughout the process. Design thinking is a framework that promotes creative problem-solving while using techniques that make ambiguity […]Diana M Sobieraj
- Meta-analysis of predictors of healthcare-associated <em>Clostridioides difficile</em> infection November 20, 2024Our systematic review and meta-analysis of 40 studies (n = 3,905,559) identified gastric acid suppressants, recent hospitalization, antibiotic exposure, and certain comorbidities as independent predictors of healthcare-associated Clostridioides difficile infection (HA-CDI) among adult inpatients. Targeted antibiotic stewardship and judicious use of gastric acid suppressants can reduce the incidence of HA-CDI.Jesse Fajnzylber
- Donor pulmonary hemodynamics does not impact recipient outcomes in adult heart transplantation November 18, 2024CONCLUSIONS: Donor pulmonary pressures did not impact post-heart transplant survival in adult recipients. Donors with abnormal pulmonary hemodynamics remain viable donor hearts for transplantation.Zeina Jedeon
- Determining Ideal Practices for Student Course Evaluations Using a Modified Delphi Approach November 16, 2024CONCLUSION: This Delphi study established consensus on approaches programs can use to optimize SCEs, according to experts from across the academy. Though some items are very specific, there are opportunities for individualization based on program priorities.Aleda M H Chen
This RSS feed was created from a PubMed search that included the following facets: Keyword: Pharma*; Affiliation: University of Connecticut; Author: Faculty last names and initials. Some publications may be excluded from this list due to the timing of indexing in PubMed or lack of metadata standardization across publishers.