Pikal Symposium

Dr. Steven L. Nail retired from the position of Senior Research Scientist at Baxter Biopharma Solutions, Bloomington, IN. His career spanned almost 50 years specializing in the development and manufacture of parenteral products, with a special interest in the science and technology of freeze-drying. Dr. Nail is a Fellow of the American Association of Pharmaceutical Scientists. In 2007, he received the AAPS Research Achievement Award in Pharmaceutical Technology. He served as Guest Editor for the September 2009 issue of Journal of Pharmaceutical Sciences dedicated to Professor Pikal.

August 13-14, 2024 Pre-conference Short Course

August 14, 2024, Pharmacy Biology Building (School of Pharmacy), Room PBB 131

1:30pm-2:00pm Registration

2:00 pm-2:15 pm Welcome- Robin H. Bogner

2:15 pm -2:30 pm Opening Remarks- Dean Philip Hritcko

Scientific Session 1. Moderator: Yongchao Su, Senior Principal Scientist, Merck

2:30 pm-3:00 pm Robin H. Bogner, Professor, University of Connecticut

Slow is Fast: Reducing the Primary Drying Time by Slow Freezing by Controlled Ice Nucleation or Annealing

3:00pm-3:30 pm Serguei Tchessalov, Research Fellow, Pfizer

Spray Freeze-Drying of Pharmaceuticals – The Future is Close

3:30pm-4:00 pm Emily Gong, Principal Scientist, Physical Sciences Incorporated

Formulation Dependent Absorption of Microwave Energy and the Effect on Drying Rates

4:00 pm-4:30 pm Panel Discussions

4:30pm-6:00pm Free time

6:00 pm-7:30 pm Reception & Buffet dinner, The Graduate Storrs Hotel

7:30 pm-8:15 pm Pikal Family Welcome- Mary, Amy, and Kathy

Steven L. Nail - Keynote Address

Pharmaceutical Freeze-Drying: A Look Back, and a Look Ahead

August 15, 2024, Pharmacy Biology Building (School of Pharmacy), Room PBB 131

7:30 am-8:30 am Breakfast

Scientific Session 2. Moderator: Sajal Patel, Senior Director, AstraZeneca

8:30 am -9:00 am Raj Suryanarayanan, William and Mildred Peters Endowed Chair, University of Minnesota

Implications of Excipient Phase Behavior on Protein Stability

9:00 am -9:30 am Yongchao Su, Senior Principal Scientist, Merck

Physiochemical Learnings of Pharmaceutical Frozen Solution from Solid-State NMR Spectroscopy

9:30 am -10:00 am Sarah Strangfeld, Scientist, Early Stage Formulation Sciences, AstraZeneca

A Solid Case for Lyophilized Antibody Drug Conjugates

10:00 am-10:30 am Break & Posters

10:30 am-11:00 am Lauren Fontana, Associate Director, Biologics Drug Product Development & Manufacturing and Global Head Lyophilization Center of Excellence, Sanofi & Navpreet Kaur, Scientist, Biologics Drug Product Development & Manufacturing, Sanofi

Demystifying Fogging in Lyophilized Products

11:00 am-11:30 am Xiuling Lu, Professor, University of Connecticut

Impact of Lyoprotectants and Freeze-drying Process on Nanoparticle Stability

11:30 am-12:00 pm Panel Discussion

12:00 pm-12:45 pm Lunch

12:45 pm-1:30 pm Poster Session

Scientific Session 3. Moderator: Bakul Bhatnagar, Associate Research Fellow , Pfizer Inc.

1:30 pm-2:00 pm Alina Alexeenko, Sr. Assoc. Dean and Professor, Purdue University

Harnessing Microwave Energy and Microscale Transport for Next-Generation Lyophilization Systems

2:00 pm-2:30 pm Kohsaku Kawakami, Group Leader, Japanese National Institute for Materials Science

Lyophilization to Manufacture Mesoporous Phospholipid Particles

2:30 pm-3:00 pm Xiaolin “Charlie” Tang, Principal Fellow, Regeneron

Advances in Protein Drug Product Lyophilization: Strategies to Improve Lyophilized Protein Drug Product

3:00 pm-3:30 pm Break (UConn Dairy Bar Ice Cream)

3:30 pm-4:00 pm Jayasree Srinivasan, Research Scientist II, Simtra BioPharma Solutions

Graphical Design Space for Primary Drying: Sources of Variability

4:00 pm-4:30 pm Panel Discussion

4:30pm-4:40pm Closing Remarks-Xiuling Lu

5:30 pm-8:00 pm Cocktail and Buffet Dinner, Pharmacy Biology Building (School of Pharmacy), Morosko Lounge

Serguei Tchessalov, Research Fellow, Pfizer

Kohsaku Kawakami, Group Leader, Japanese National Institute for Materials Science

Yongchao Su, Senior Principal Scientist, Merck

Alina Alexeenko, Sr. Assoc. Dean and Professor, Purdue University

Raj Suryanarayanan, William and Mildred Peters Endowed Chair, University of Minnesota

Emily Gong, Principal Research Scientist, Physical Sciences Incorporated

Robin H. Bogner, Professor, University of Connecticut

Xiuling Lu, Professor, University of Connecticut

Lauren Fontana, Associate Director, Biologics Drug Product Development & Manufacturing and Global Head Lyophilization Center of Excellence, Sanofi

Navpreet Kaur, Scientist, Biologics Drug Product Development & Manufacturing, Sanofi

Xiaolin “Charlie” Tang, Principal Fellow, Regeneron

Sarah Strangfeld, Scientist, Early Stage Formulation Sciences, AstraZeneca

Jayasree Srinivasan, Research Scientist II, Simtra BioPharma Solutions