Case Studies in Drug Interactions with Anticoagulation Therapy

If desired, “bundle” pricing can be obtained by registering for the activities in groups. It consists of thirteen anticoagulation activities in our online selection.

You may register for individual topics at $17/CE Credit Hour, or for the Entire Anticoagulation Pre-requisite Series.

Pharmacist General Registration for 13 Anticoagulation Pre-requisite activities-(12 hours of CE)  $140.00

In order to attend the 2-day Anticoagulation Traineeship, you must complete all of the Pre-requisite Series or the equivalent.

Anticoagulation Traineeship at the University of Connecticut Health Center, Farmington, CT

The University of Connecticut School of Pharmacy and The UConn Health Center Outpatient Anticoagulation Clinic have developed 2-day practice-based ACPE certificate continuing education activity for registered pharmacists and nurses who are interested in the clinical management of patients on anticoagulant therapy and/or who are looking to expand their practice to involve patient management of outpatient anticoagulation therapy. This traineeship will provide you with both the clinical and administrative aspects of a pharmacist-managed outpatient anticoagulation clinic. The activity features ample time to individualize your learning experience. A “Certificate of Completion” will be awarded upon successful completion of the traineeship.

More Information About Traineeship

To receive CE Credit go to Blue Button labeled "take Test/Evaluation" at the top of the page.

Type in your NABP ID, DOB and the session code for the activity.  You were sent the session code in your confirmation email.

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1. You are not familiar with drug X. How would you determine if a drug interaction is likely between drug X and warfarin?

1. Check drug X prescribing information
2. Evaluate metabolic characteristics of drug X
3. Review case reports through Medline
4. Request information from the manufacturers of warfarin
5. All of the above

2.Warfarin is a racemic mixture of both R- and S- warfarin. What is the primary route of elimination for the S-warfarin version of this racemic mixture?

1. Renal
2. Hepatic CYP1A2, CYP3A4
3. Hepatic CYP2C15
4. Hepatic CYP2C9

3. Acute alcohol use “binge drinking” would have what effect on the INR of a patient who has been stable on warfarin anticoagulation therapy?

1. INR value would go down
2. INR value would remain the same
3. INR value would go up
4. None of the above

Patient Case:

JM is a 35 YO female with a history of DVT and is on chronic warfarin therapy with an INR goal of 2.0-3.0.  JM is not taking any other meds and has discontinued her birth control tablets several years earlier due to the association with her developing a DVT.  JM decides to self-treat what is believed to be a vaginal yeast infection with miconazole nitrate vaginal cream for 7 days.

4. Based upon the information provided in this patient case should you be concerned about JM self-treating her yeast infection?

1. Yes
2. No
3. Undecided

5. Based upon the information provided in this case what would you expect to happen to JM’s INR level after 3-4 days of her using the miconazole nitrate vaginal cream?

1. INR would go up
2. INR would remain the same
3. INR would go down
4. None of the above

6. Based upon the information that you have on patient JM when should you schedule her next INR testing time?

1. Recheck INR in 1 month
2. Recheck INR in 2 weeks
3. Recheck INR in 3-4 days
4. Recheck INR in 90 days

7. Warfarin decreases the production of which of the following vitamin K dependent clotting factors?

1. II
2. VII
3. IX
4. X
5. All of the above

8. Which of the following best describes examples of pharmacodynamic mechanisms for drug interactions?

1. Protein binding
2. Enzyme induction
3. Synergism
4. None of the above

9. Which of the following oral anticoagulant agents currently has an approved reversal agent to reverse their anticoagulant actions?

1. Fondaparinux
2. Rivaroxaban
3. Warfarin
4. Dabigatran
5. Both c and d above

10. The best over-the-counter (OTC) self-treatment option for a patient with minor headaches, aches and pains who is also taking warfarin is acetaminophen (APAP). Why would you recommend APAP over aspirin or NSAIDs to a patient on warfarin?

1. APAP does not inhibit platelet function
2. APAP does not cause injury to the GI mucosa
3. APAP is highly protein bound
4. Both a and b above

Vitamin K Antagonist Pharmacology, Pharmacotherapy and Pharmacogenomics – 1 hour

Anticoagulation Management Pearls - 1 hour

Direct Oral Anticoagulants and Factor IIa and Xa Inhibitors – 1 hour

Laboratory Monitoring of Anticoagulation – 1 hour

Heparin/Low Molecular Weight Heparin and Fondaparinux Pharmacology and Pharmacotherapy – 0.5 hours

Developing an Anticoagulation Clinic – 1.0 hour

Pharmacist Reimbursement for Anticoagulation Services – 0.5 hour

Risk Management in Anticoagulation – 1 hour

Perioperative Management of Warfarin Interruption – 1 hour

Hypercoagulable States – 1 hour

Challenging Topics in Anticoagulation – 1 hour

Available Strategies to Reverse Anticoagulation Medications - 1 hour

Case Studies in Drug Interactions with Anticoagulation Therapy – 1 hour