Continuing Pharmacy Education / CE Master List / Vitamin K Antagonist Pharmacology, Pharmacotherapy and Pharmacogenomics
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Vitamin K Antagonist Pharmacology, Pharmacotherapy and Pharmacogenomics

About this Course

UConn has developed web-based continuing pharmacy education activities to enhance the practice of pharmacists and assist pharmacists in making sound clinical decisions to affect the outcome of anticoagulation therapy for the patients they serve. There are a total of 12 hours of CPE credit available. Successful completion of these 12 hours (13 activities) or equivalent training will prepare the pharmacist for the Anticoagulation Traineeship, which described below in the Additional Information Box.

The activities below are available separately for $17/hr or as a bundle price of $140 for all 13 activities (12 hours). These are the pre-requisites for the anticoagulation traineeship. Any pharmacist who wishes to increase their knowledge of anticoagulation may take any of the programs below.

When you are ready to submit quiz answers, go to the Blue "Take Test/Evaluation" Button.

Target Audience

Pharmacists who are interested in making sound clinical decisions to affect the outcome of anticoagulation therapy for the patients they serve.

This activity is NOT accredited for technicians.

Pharmacist Learning Objectives

At the end of this knowledge-based continuing education activity, the learner will be able to:

  1. Discuss the pharmacology of the vitamin K antagonist.
  2. Discuss the indications and contraindications for the vitamin K antagonists.
  3. Discuss the role genetics plays in the dosing of warfarin.
  4. Discuss the utility of how genetic testing will affect initial dosing of warfarin.

Release Date

Released:  06/01/2022
Expires:  05/31/2025

Course Fee

$17

ACPE UAN Codes

ACPE #0009-0000-22-030-H01-P

Accreditation Hours

1.0 hours of CE

Bundle Options

If desired, “bundle” pricing can be obtained by registering for the activities in groups. It consists of thirteen anticoagulation activities in our online selection.

You may register for individual topics at $17/CE Credit Hour, or for the Entire Anticoagulation Pre-requisite Series.

Pharmacist General Registration for 13 Anticoagulation Pre-requisite activities-(12 hours of CE)  $140.00

In order to attend the 2-day Anticoagulation Traineeship, you must complete all of the Pre-requisite Series or the equivalent.

Additional Information

Anticoagulation Traineeship at the University of Connecticut Health Center, Farmington, CT

The University of Connecticut School of Pharmacy and The UConn Health Center Outpatient Anticoagulation Clinic have developed 2-day practice-based ACPE certificate continuing education activity for registered pharmacists and nurses who are interested in the clinical management of patients on anticoagulant therapy and/or who are looking to expand their practice to involve patient management of outpatient anticoagulation therapy. This traineeship will provide you with both the clinical and administrative aspects of a pharmacist-managed outpatient anticoagulation clinic. The activity features ample time to individualize your learning experience. A “Certificate of Completion” will be awarded upon successful completion of the traineeship.

More Information About Traineeship

Accreditation Statement

ACPE logo

The University of Connecticut, School of Pharmacy, is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.  Statements of credit for the online activity ACPE #0009-0000-22-030-H01-P will be awarded when the post test and evaluation have been completed and passed with a 70% or better. Your CE credits will be uploaded to your CPE monitor profile within 2 weeks of completion of the program.

Grant Funding

There is no grant funding for this activity.

Requirements for Successful Completion

To receive CE Credit go to Blue Button labeled "take Test/Evaluation" at the top of the page.

Type in your NABP ID, DOB and the session code for the activity.  You were sent the session code in your confirmation email.

Faculty

Jenna Lee, PharmD,
Supervisor
Ambulatory Care Clinical Pharmacy Services
Yale New Haven Hospital
New Haven, CT

Faculty Disclosure

In accordance with the Accreditation Council for Pharmacy Education (ACPE) Criteria for Quality and Interpretive Guidelines, The University of Connecticut School of Pharmacy requires that faculty disclose any relationship that the faculty may have with commercial entities whose products or services may be mentioned in the activity.

Dr. Lee has no relationship with an ineligible company and therefore has nothing to disclose.

Disclaimer

The material presented here does not necessarily reflect the views of The University of Connecticut School of Pharmacy or its co-sponsor affiliates. These materials may discuss uses and dosages for therapeutic products, processes, procedures and inferred diagnoses that have not been approved by the United States Food and Drug Administration. A qualified health care professional should be consulted before using any therapeutic product discussed. All readers and continuing education participants should verify all information and data before treating patients or employing any therapies described in this continuing education activity.

Program Content

Program Handouts

Post Test Evaluation

View Questions for Vitamin K Antagonist Questions

1. Which of the following is NOT a catalyst for the coagulation cascade?
a. Tissue Factor
b. Collagen
c. Negatively charged phospholipid surfaces
d. Positively charged phospholipid surfaces

2. The following is true regarding VKOR, except:
a. It is an enzyme
b. It is the target of warfarin’s mechanism of action
c. It binds to negatively charged phospholipids in the presence of calcium
d. It recycles vitamin K epoxide to active vitamin KH2

3. Which if the following is not a contraindication for warfarin therapy?
a. Pregnancy
b. Major surgery or trauma
c. Active bleeding
d. Spinal puncture
e. Asymptomatic PE

4. DE is a 60 year old male being referred to your anticoagulation clinic with a diagnosis of new onset atrial fibrillation. DE’s past medical history is significant for hypertension, hypercholesterolemia, rheumatoid arthritis, and type 2 diabetes mellitus. Based on the CHEST guidelines, what duration of warfarin therapy do you recommend for DE? Why?
a. 3 months to indefinite, CHADS score of 2
b. Indefinite, CHADS score of 4
c. Indefinite, CHADS score of 2
d. Aspirin therapy preferred over warfarin in this patient
e. None of the above

5. ML is a 65 year old female being referred to your anticoagulation clinic with a s/w new mechanical heart valve in the mitral position. What duration of warfarin therapy and INR goal do you recommend for ML?
a. 2-3; Indefinite therapy
b. 2-3; 3-6 months
c. 2.5-3.5; Indefinite therapy
d. 2.5-3.5; 3-6 months
e. 1.5-2; Indefinite therapy
f. Warfarin is not recommended

6. AL is a 48 year old female who is on warfarin therapy with an indication of mechanical heart valve in the aortic position. Her INR goal is 2-3. Today AL’s INR returned at 1.6. She reports no pertinent findings. The patient take 7.5 mg on Monday and 5 mg on all other days.
a. What are your next steps for this patient?
b. No Change. Continue current warfarin dosing.
c. Instruct the patient to take warfarin 5 mg daily
d. Instruct the patient to take warfarin 7.5 mg on M/F and 5 mg on all other days
e. Instruct the patient to take warfarin 10 mg daily
f. Contact the clinician. The patient’s INR goal is incorrect

7. When considering warfarin dosage adjustments, which of the following patient specific factors is important to consider?
a. Dietary vitamin K intake
b. Upcoming dental procedure
c. Newly started amiodarone
d. History of patient non-adherence
e. All of the above